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Rare disease's mutation could explain more common conditions
Medical Xpress· 3 hours agoTREX1 is a gene that is supposed to direct the maintenance of the entire body's DNA, but new...
Proteomics uncover sexual dimorphism and immune changes in aging mice with Werner syndrome
Medical Xpress· 22 hours agoA new research paper titled "Integrated liver and serum proteomics uncover sexual dimorphism and alteration of several immune response proteins in an aging Werner syndrome mouse mode" has been published in Aging.
New Form of Male Birth Control 100% Effective in Mice
Medscape· 14 hours agoA new candidate has emerged in the quest for a male birth control pill. Researchers at Baylor...
NIH, MSKCC researchers publish AI model for predicting immunotherapy responses
FierceBiotech· 2 hours agoThe AI model incorporates five clinical features gathered from a routine workup and blood testing:...
Research team creates mice that better reflect human genetic variation
Medical Xpress· 6 days agoBeth Dumont, an evolutionary biologist at The Jackson Laboratory, and colleagues are looking to...
New study highlights potential of covalent radioligands in cancer treatment
Medical Xpress· 4 hours agoThe ionizing radiation emitted by radioactive substances attached to the carrier destroys cancer cells by damaging their DNA, leading to the reduction of tumors. To simplify ...
Engineered DNA 'warhead' targets a common cancer mutation
Medical Xpress· 5 days agoTumor protein P53 (TP53) plays an important role in suppressing the growth of tumors. Mutations in the gene for TP53 can have a disastrous effect, hampering the body's ability to fight tumors ...
Transgene removal using an in cis programmed homing endonuclease via single-strand annealing in the...
Nature· 7 days agoThis study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits - Nature...
Nature· 7 days agoPdCO is a switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo, as demonstrated in a variety of contexts mainly in the mouse.
SGLT2 inhibition eliminates senescent cells and alleviates pathological aging - Nature Aging
Nature· 6 days agoKatsuumi, Shimizu, Suda et al. report that SGLT2 inhibition reduces the senescence burden and alleviates aging traits in mice. The authors demonstrate an indirect mechanism of senescent cell removal, through enhancing immunosurveillance.