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Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 7 hours agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny...
Nature· 10 hours agoAutism spectrum disorders (ASDs) are known to present sex-specific differences. At the same time, understanding how maternal behaviours are affected by pathogenic mutations is crucial to translate ...
What is science? Tech heavyweights brawl over definition
Nature· 14 hours agoAI pioneer Yann LeCun and Elon Musk went head-to-head in a debate about modern research that drew...
Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability - Molecular...
Nature· 1 day agoAs the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor (SSRI) class represent prime candidates for drug ...
Reduced precipitation can induce ecosystem regime shifts in lakes by increasing internal nutrient...
Nature· 1 day agoEutrophication is a main threat to continental aquatic ecosystems. Prevention and amelioration actions have been taken under the assumption of a stable climate, which needs reconsideration.
Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing...
Nature· 1 day agoSingle-cell atlas of Microhyla fissipes lungs reveals cell differentiation and functionalization during metamorphosis, further cross-species comparison sheds light vertebrate lung cell type evolution.
Detection of inflammasome activation in liver tissue during the donation process as potential...
Nature· 1 day agoDeceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated ...
Transgene removal using an in cis programmed homing endonuclease via single-strand annealing in the...
Nature· 2 days agoThis study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
Neural correlates of obesity across the lifespan - Communications Biology
Nature· 3 days agoThis study reveals that obesity-related brain changes evolve across the lifespan and involve mitochondrial and inflammatory genes, as well as neurochemical and cognitive alterations.
Bio-stimulating effect of endophytic Aspergillus flavus AUMC 16068 and its respective...
Nature· 6 days agoHeavy metal accumulation is one of the major agronomic challenges that has seriously threatened food safety. As a result, metal-induced phytotoxicity concerns require quick and urgent action ...