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Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice...
Nature· 16 hours agoProdromal gut inflammation exacerbates Parkinson’s disease endophenotypes in mouse carriers of human LRRK2 G2019S in a sex-dependent manner, showing increased α-synuclein positive macrophages in the colon and brain microglia.
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis - Nature...
Nature· 16 hours agoThe endoplasmic reticulum (ER) is a major site of lipid peroxidation during ferroptosis. Here authors show that the ER protein IRE1α determines ferroptosis induction via regulating glutathione synthesis independent of the unfolded protein response.
Selective venous sampling for secondary hypertension - Hypertension Research
Nature· 16 hours agoThese authors contributed equally to this work.
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated...
Nature· 16 hours agoHypoxia-ischemia (HI) is one of the main causes of neonatal brain injury. Mitophagy has been implicated in the degradation of damaged mitochondria and cell survival following neonatal brain ...
Experimental obesity drug packs double punch to reduce weight
Nature· 23 hours agoTest of weight-loss candidate in mice shows that there is still room for improvement in a burgeoning...
Cutaneous squamous cell carcinoma characterized by MALDI mass spectrometry imaging in combination...
Nature· 16 hours agoCutaneous squamous cell carcinoma (SCC) is an increasingly prevalent global health concern. Current diagnostic and surgical methods are reliable, but they require considerable resources and ...
US to send an unofficial delegation as Taiwan's president is sworn in. It will test ties with China
Associated Press via AOL· 9 hours agoA senior White House official said the move is in line with longstanding U.S. practice to send the...
‘Quantum internet’ demonstration in cities is most advanced yet
Nature· 23 hours agoExperiments generate quantum entanglement over optical fibres across three real cities, marking...
Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung...
Nature· 2 days agoLung adenocarcinoma (LUAD) is one of the most prevalent types of cancer. Ubiquitination is crucial in modulating cell proliferation and aerobic glycolysis in cancer. The frequency of TP53 mutations ...
Hypoxia inhibits ferritinophagy-mediated ferroptosis in esophageal squamous cell carcinoma via the...
Nature· 2 days agoEsophageal squamous cell carcinoma (ESCC) is a prevalent malignancy of the digestive system. Hypoxia is a crucial player in tumor ferroptosis resistance. However, the molecular mechanism of ...