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Uncommon opsin’s retinal isomer is involved in mammalian sperm thermotaxis - Scientific Reports
Nature· 1 day agoIn recent years it became apparent that, in mammals, rhodopsin and other opsins, known to act as photosensors in the visual system, are also present in spermatozoa, where they function as highly ...
Testing functional anchor groups for the efficient immobilization of molecular catalysts on silver...
Nature· 1 day agoThiolate groups are promising anchors to immobilize catalysts, particularly on coinage metal surfaces, but the anchor group’s impact on the local adsorption configuration of the catalyst is ...
Fluorescence imaging sheds light on the immune evasion mechanisms of hepatic stellate cells mediated...
Nature· 24 hours agoUsing two-photon fluorescence imaging, the authors show that superoxide anion in hepatic stellate cells impairs the infiltration of CD8+ T cells in a mouse model of hepatocellular carcinoma.
Targeting CXCR4 impaired T regulatory function through PTEN in renal cancer patients - British...
Nature· 7 days agoTregs trafficking is controlled by CXCR4. In Renal Cell Carcinoma (RCC), the effect of the new CXCR4 antagonist, R54, was explored in peripheral blood (PB)-Tregs isolated from primary RCC patients ...
Estimating neutrosophic finite median employing robust measures of the auxiliary variable -...
Nature· 7 days agoOur study explores neutrosophic statistics, an extension of classical and fuzzy statistics, to address the challenges of data uncertainty. By leveraging accurate measurements of an auxiliary ...
BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation -...
Nature· 2 days agoThe N-BAR domain protein BIN1 acts as a scaffolding protein during filopodia formation in myoblast cells, together with identified co-factors.
Dishevelled2 activates WGEF via its interaction with a unique internal peptide motif of the GEF -...
Nature· 4 days agoThis study identifies a unique “internal-PDZ binding motif” (IPM) of WGEF that mediates its interaction with Dvl2PDZ, leading to the release of GEF from its autoinhibitory state. It further unravels the underlying mutual Dvl2-IPM recognition aspects.
Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in...
Nature· 7 days agoSensory abnormalities are observed in ~90% of individuals with autism spectrum disorders (ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor subunit that regulates ...
Hyperthyroidism-driven bone loss depends on BMP receptor Bmpr1a expression in osteoblasts -...
Nature· 3 days agoComparison of the bone phenotypes of hyperthyroid versus euthyroid bone cell-specific conditional knockout mice suggests that the osteoblastic, but not osteoclast, BMP receptor BMPR1A is a main driver of hyperthyroidism-associated bone disease.
Subaerial weathering drove stabilization of continents - Nature
Nature· 3 days agoThe geological histories of Archaean regions indicate that stabilization of the Earth’s continents and the formation of cratons was driven by continental emergence and subaerial weathering.