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A ResNet mini architecture for brain age prediction - Scientific Reports
Nature· 9 hours agoThe brain presents age-related structural and functional changes in the human life, with different extends between subjects and groups. Brain age prediction can be used to evaluate the development ...
Fibroblasts’ secretome from calcified and non-calcified dermis in Pseudoxanthoma elasticum...
Nature· 9 hours agoAn in vitro study on fibroblasts from clinically affected or unaffected skin of patients with Pseudoxanthoma elasticum indicates that local microenvironment guides the level of matrix remodeling and the extent of elastic fiber calcification.
Sustained attention operates via dissociable neural mechanisms across different eccentric locations...
Nature· 9 hours agoIn primates, foveal and peripheral vision have distinct neural architectures and functions. However, it has been debated if selective attention operates via the same or different neural mechanisms ...
Impairing hydrolase transport machinery prevents human melanoma metastasis - Communications Biology
Nature· 1 day agoAn in vitro and in vivo study using human melanoma cell lines suggests that perturbing lysosomal function stimulates lysosome biogenesis and decreases invasiveness potential.
Phosphoglycerate mutase 1 promotes breast cancer progression through inducing immunosuppressive M2...
Nature· 1 day agoImmunosuppressive tumor microenvironment (TME) contributes to tumor progression and causes major obstacles for cancer therapy. Phosphoglycerate mutase 1 (PGAM1) is a key enzyme involved in cancer ...
Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice...
Nature· 1 day agoProdromal gut inflammation exacerbates Parkinson’s disease endophenotypes in mouse carriers of human LRRK2 G2019S in a sex-dependent manner, showing increased α-synuclein positive macrophages in the colon and brain microglia.
Do ‘Parentified Children’ Really Have It So Bad?
The Cut· 5 hours agoYou may have been a “parentified child.” Like gaslighting and narcissism before it, parentification is a pop-psychology term in the ascent. “Being a...
PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated...
Nature· 1 day agoHypoxia-ischemia (HI) is one of the main causes of neonatal brain injury. Mitophagy has been implicated in the degradation of damaged mitochondria and cell survival following neonatal brain ...
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis - Nature...
Nature· 1 day agoThe endoplasmic reticulum (ER) is a major site of lipid peroxidation during ferroptosis. Here authors show that the ER protein IRE1α determines ferroptosis induction via regulating glutathione synthesis independent of the unfolded protein response.
Cutaneous squamous cell carcinoma characterized by MALDI mass spectrometry imaging in combination...
Nature· 1 day agoCutaneous squamous cell carcinoma (SCC) is an increasingly prevalent global health concern. Current diagnostic and surgical methods are reliable, but they require considerable resources and ...