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Fluorescent fatty acid conjugates for live cell imaging of peroxisomes - Nature Communications
Nature· 6 days agoThe array of tools to image peroxisome regulation is still limited. Here, the authors develop improved fatty acid-based probes with high peroxisome specificity and bright fluorescence in the ...
LINE-1 retrotransposons contribute to mouse PV interneuron development - Nature Neuroscience
Nature· 6 days agoLINE-1 retrotransposons are a type of mobile DNA element normally repressed in the body. Here the authors show that LINE-1 sequences can jump in mouse parvalbumin interneurons and also promote the transcription of key parvalbumin interneuron genes.
The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells -...
Nature· 4 days agoThis study reports a unexpected role in endothelial cells (ECs) for PCK2 in proteostasis, independent of its gluconeogenic activity. Perturbation of this role likely contributed to the angiogenic defects observed in ECs with reduced PCK2 levels.
Population-based nanopore sequencing of the HIV-1 pangenome to identify drug resistance mutations -...
Nature· 10 hours agoHIV-1 drug resistance genotypic tests have primarily been performed by Sanger sequencing of gene segments encoding different drug target proteins. Since the number of targets has increased with ...
What’s to blame for sudden demise of chitalpa tree?
Las Vegas Review-Journal· 2 days agoThis is where the disease is located. Yellow leaves are only a “symptom” recorded by the leaves. Once this disease gets into the trunk, the tree is a...
Quick takes: US FLiRT variant proportions rise, Angola reports first polio case, FDA norovirus...
Center for Infectious Disease Research and Policy· 3 days agoThe FLiRT variants are fueling new waves some countries, but so far the US markers don't show major...
IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing...
Nature· 5 days agoCircular RNAs (circRNAs) represent a class of covalently closed, single-stranded RNAs and have been linked to cancer progression. N6-methyladenosine (m6A) methylation is a ubiquitous RNA modification ...
CDC: Salmonella Outbreaks Linked to Backyard Poultry
Centers for Disease Control and Prevention· 4 days agoCDC and public health officials in several states are collecting different types of data to investigate multistate outbreaks of Salmonella Altona,...
'Fire blight' bacteria a new challenge for apple trees in the Northeast
Berkshire Eagle· 5 days agoThree years ago, I planted a little orchard of 20 dwarf cider apple trees. Now I am wondering about...
Oxford Nanopore Technologies Eyes TB Test as First In-House-Developed Diagnostic Test
GenomeWeb News· 4 days agoOxford Nanopore Technologies has been working on a tuberculosis drug resistance sequencing assay that it hopes will become its first in vitro diagnostic test developed in house. Dubbed Ampore-TB ...