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Neural correlates of obesity across the lifespan - Communications Biology
Nature· 6 days agoThis study reveals that obesity-related brain changes evolve across the lifespan and involve mitochondrial and inflammatory genes, as well as neurochemical and cognitive alterations.
Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders -...
Nature· 6 days agoExcitation/inhibition (E/I) balance plays important roles in mental disorders. Bioactive phospholipids like lysophosphatidic acid (LPA) are synthesized by the enzyme autotaxin (ATX) at cortical ...
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel...
Nature· 5 days agoCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were ...
Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability - Molecular...
Nature· 4 days agoAs the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor (SSRI) class represent prime candidates for drug ...
Unlocking bacterial potential to reduce farmland N2O emissions - Nature
Nature· 5 days agoA study presents a method to mitigate emissions of nitrous oxide from farmland using bacteria to consume nitrous oxide in soil with organic waste as a substrate and vector.
Local dominance unveils clusters in networks - Communications Physics
Nature· 3 days agoCommunity detection has been studied for more than 20 years, but a perspective from community center is still missing and most algorithms need global information. The authors propose a linear ...
DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression -...
Nature· 5 days agoType 1 insulin-like growth factor receptor (IGF1R) plays an important role in cancer, however, posttranscriptional regulation such as N6-methyladenosine (m6A) of IGF1R remains unclear. Here, ...
Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny...
Nature· 3 days agoAutism spectrum disorders (ASDs) are known to present sex-specific differences. At the same time, understanding how maternal behaviours are affected by pathogenic mutations is crucial to translate ...
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by...
Nature· 4 days agoDegenerated endplate appears with cheese-like morphology and sensory innervation, contributing to low back pain and subsequently inducing intervertebral disc degeneration in the aged population ...
Reduced precipitation can induce ecosystem regime shifts in lakes by increasing internal nutrient...
Nature· 4 days agoEutrophication is a main threat to continental aquatic ecosystems. Prevention and amelioration actions have been taken under the assumption of a stable climate, which needs reconsideration.
