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New mechanism of immune evasion in squamous cell carcinoma offers potential for improved treatment
Medical Xpress· 7 days agoA research group has revealed the tumor-extrinsic function of master regulator transcription...
CRISPR-based mapping uncovers 'switches' for immune genes central to health
Medical Xpress· 2 days agoWhile scientists have long recognized the vital function of these neighboring genes, much less is known about how they're switched on and off in specialized T cells that suppress the
Scientists find 'Goldilocks' binding strength determines anti-cancer T-cell efficacy and fate
Medical Xpress· 20 hours agoSt. Jude Children's Research Hospital scientists found that how tight a parental T cell grabs a cancer protein determines if its daughter cells will be anti-cancer effectors or exhausted. T ...
Researchers identify immune dysfunction as a possible aspect of polycystic ovary syndrome pathology
Medical Xpress· 4 days agoSince concurrent treatment with an androgen receptor antagonist prevented many changes in the mouse model used in the study, combination therapies that include both anti-androgens and other ...
New study reveals key protein that could help prevent excessive bone loss in osteoporosis
Medical Xpress· 15 hours agoWith the aging population experiencing a surge in osteoporosis cases, the strain on health care...
New study highlights senescent cell removal mechanisms of canagliflozin, a sodium glucose...
Medical Xpress· 1 day agoThe process of aging is accompanied by a decline in physiological functions, which can lead to...
Molecular Assassins: How Azoles Cause Fungal Pathogens to Self-Destruct
SciTechDaily· 2 hours agoNew research led by the University of Exeter shows that azole antifungals trigger self-destruction...
Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 5 hours agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Q&A: Illuminating the mechanisms behind severe inflammation in asthma
Medical Xpress· 20 hours agoJoshua A. Boyce, MD, chief of the Division of Allergy and Clinical Immunology at Brigham and Women's...
All Over the Map? Mechanisms of ICI Acquired Resistance in NSCLC
MedPage Today· 7 days ago"Resistance is futile." What's less debatable, though, is that patients with non-small cell lung...