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Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide...
Nature· 4 days agoGenome-wide association study (GWAS) is a powerful tool to identify genomic loci underlying complex traits. However, the application in natural populations comes with challenges, especially ...
Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 4 days agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Molecular entanglement can strongly increase basicity - Communications Chemistry
Nature· 7 days agoBrønsted basicity can be greatly enhanced by the mechanical entanglement of two or more interlocked molecular subunits within catenanes and rotaxanes. Here, the authors discuss the development ...
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by...
Nature· 5 days agoDegenerated endplate appears with cheese-like morphology and sensory innervation, contributing to low back pain and subsequently inducing intervertebral disc degeneration in the aged population ...
Transgene removal using an in cis programmed homing endonuclease via single-strand annealing in the...
Nature· 6 days agoThis study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic...
Nature· 7 days agoSplicing factors are frequently mutated in patients with myelodysplastic syndromes and acute myeloid leukaemia. Recent studies have revealed convergent molecular defects caused by splicing factor ...
Detection of inflammasome activation in liver tissue during the donation process as potential...
Nature· 5 days agoDeceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated ...
Neural correlates of obesity across the lifespan - Communications Biology
Nature· 7 days agoThis study reveals that obesity-related brain changes evolve across the lifespan and involve mitochondrial and inflammatory genes, as well as neurochemical and cognitive alterations.
Open questions on carbonaceous matter in meteorites - Communications Chemistry
Nature· 6 days agoExtraterrestrial carbon gives insights into the origin of life and processes that took place billions of years ago in our solar system. Here, the authors provide an overview of what is known and of unanswered questions with a meteoritical focus.
Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to...
Nature· 6 days agoDespite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing propionate production from the ...