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Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing...
Nature· 6 days agoSingle-cell atlas of Microhyla fissipes lungs reveals cell differentiation and functionalization during metamorphosis, further cross-species comparison sheds light vertebrate lung cell type evolution.
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial...
Nature· 7 days agoDiabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is characterized by heightened endothelial apoptosis ...
Transgene removal using an in cis programmed homing endonuclease via single-strand annealing in the...
Nature· 7 days agoThis study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
Detection of inflammasome activation in liver tissue during the donation process as potential...
Nature· 6 days agoDeceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated ...
Cryo-EM structure of cadmium-bound human ABCB6 - Communications Biology
Nature· 5 days agoCryo-EM structure of human ATP-binding cassette transporter 6 (ABCB6) in complex with Cd(II) and glutathione (GSH) provides molecular insight into its dual role, essential for heme biosynthesis and as a heavy metal efflux pump.
Unlocking bacterial potential to reduce farmland N2O emissions - Nature
Nature· 7 days agoA study presents a method to mitigate emissions of nitrous oxide from farmland using bacteria to consume nitrous oxide in soil with organic waste as a substrate and vector.
Aloe-inspired eco-friendly synthesis of Ag/ZnO heterostructures: boosting photocatalytic potential -...
Nature· 2 days agoThe current research focuses on the development of Ag–ZnO heterostructures through a “bottom-up” approach involving the assembly and extraction of Aloe barbadensis Miller gel. These heterostructures ...
Hope for global pandemic treaty rises — despite missed deadline
Nature· 2 days agoDelegates were at an impasse over key issues, but agreements on other public-health emergency...
Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to...
Nature· 7 days agoDespite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing propionate production from the ...
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by...
Nature· 6 days agoDegenerated endplate appears with cheese-like morphology and sensory innervation, contributing to low back pain and subsequently inducing intervertebral disc degeneration in the aged population ...