Search results
Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to...
Nature· 3 days agoCaspase-8 (Casp8) serves as an initiator of apoptosis or a suppressor of necroptosis in context-dependent manner. Members of the p90 RSK family can phosphorylate caspase-8 at threonine-265 ( ...
KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid...
Nature· 3 days agoInactivated suppressor of mothers against decapentaplegic homolog (SMAD) 4 significantly affects cancer development in pancreatic ductal adenocarcinoma (PDAC). However, the contribution of smad4 ...
Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 4 days agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
In vitro generation of genetic diversity for directed evolution by error-prone artificial DNA...
Nature· 3 days agoError-prone artificial DNA synthesis (epADS) is presented as an effective method for in vitro generation of genetic diversity for directed evolution of various types of genetic parts, synthetic gene circuits and even microbes.
Neurophysiological avenues to better conceptualizing adaptive cognition - Communications Biology
Nature· 3 days agoThis article explores novel routes to better analyze neural processes underlying the brain’s adaptability and cognitive functioning, focusing on executive functions and cognitive control. It ...
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo -...
Nature· 7 days agoUsing primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis, either via genetic ...
High-throughput investigation of stability and Li diffusion of doped solid electrolytes via neural...
Nature· 6 days agoSolid electrolytes hold substantial promise as vital components of all-solid-state batteries. Enhancing their performance necessitates simultaneous improvements in their stability and lithium ...
Mechanisms of neuromodulatory volume transmission - Molecular Psychiatry
Nature· 3 days agoA wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs from classical synaptic transmission in important ...
Construction of TiO2/WO3/TiO2 double heterojunction films for excellent electrochromic performance -...
Nature· 7 days agoElectrochromic devices are applied extensively to camouflages, smart windows, heat insulation layers, and automobile rearview mirrors, etc. The amorphous WO3 is a very attractive electrochromic ...
Enhanced quantum coherence of plasmonic resonances with a chiral exceptional points - Communications...
Nature· 5 days agoThe advent of non-Hermitian optics carries new possibilities in manipulating optical response, offering alternative ways to enhance the quantum coherence of plasmonic resonances. Based on a ...