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Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders -...
Nature· 3 days agoExcitation/inhibition (E/I) balance plays important roles in mental disorders. Bioactive phospholipids like lysophosphatidic acid (LPA) are synthesized by the enzyme autotaxin (ATX) at cortical ...
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative...
Nature· 6 days agoDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets. Spliceosome-related genes were significantly altered in HCC. Oncofetal ...
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial...
Nature· 2 days agoDiabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is characterized by heightened endothelial apoptosis ...
Molecular entanglement can strongly increase basicity - Communications Chemistry
Nature· 3 days agoBrønsted basicity can be greatly enhanced by the mechanical entanglement of two or more interlocked molecular subunits within catenanes and rotaxanes. Here, the authors discuss the development ...
Transgene removal using an in cis programmed homing endonuclease via single-strand annealing in the...
Nature· 2 days agoThis study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression -...
Nature· 2 days agoType 1 insulin-like growth factor receptor (IGF1R) plays an important role in cancer, however, posttranscriptional regulation such as N6-methyladenosine (m6A) of IGF1R remains unclear. Here, ...
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel...
Nature· 2 days agoCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were ...
Multi-wall carbon Nanotube surface-based functional nanoparticles for stimuli-responsive dual...
Nature· 4 days agoCarbon nanotubes (CNTs) have the potential to serve as delivery systems for medicinal substances and gene treatments, particularly in cancer treatment. Co-delivery of curcumin (CUR) and Methotrexate ...
Multiple environmental stressors affect predation pressure in a tropical freshwater system -...
Nature· 2 days agoField observations show that fish predators exhibit stronger association with warmer, still, clear waters. Here they exert heightened predation pressure on prey fish, highlighting the importance of ecological context in predator-prey dynamics.
PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic...
Nature· 3 days agoSplicing factors are frequently mutated in patients with myelodysplastic syndromes and acute myeloid leukaemia. Recent studies have revealed convergent molecular defects caused by splicing factor ...