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GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates...
Nature· 6 days agoSkeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 5 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to ...
Large anomalous Hall conductivity induced by spin chirality fluctuation in an ultraclean frustrated...
Nature· 5 days agoMagnetic frustration of spins often leads to nontrivial spin textures and anomalous Hall responses, but typically below the magnetic transition temperature. The authors observe a giant unconventional ...
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 3 days agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are...
Nature· 2 days agoDespite extensive characterisation of uropathogenic Escherichia coli (UPEC) causing urinary tract infections (UTIs), the genetic background of non-urinary extraintestinal pathogenic E. coli ...
Melatonin alleviates septic ARDS by inhibiting NCOA4-mediated ferritinophagy in alveolar macrophages...
Nature· 2 days agoFerroptosis is a novel form of programmed cell death which can exacerbate lung injury in septic acute respiratory distress syndrome (ARDS). Alveolar macrophages, crucial innate immune cells, ...
In vitro generation of genetic diversity for directed evolution by error-prone artificial DNA...
Nature· 2 days agoError-prone artificial DNA synthesis (epADS) is presented as an effective method for in vitro generation of genetic diversity for directed evolution of various types of genetic parts, synthetic gene circuits and even microbes.
Google's AI is teaching Pokemon fans a thing or two about LGBT pocket pals - Bulbasaur is a...
Games Radar· 14 hours agoGoogle's recent AI Overview rollout is leading to some illuminating revelations for everyone's...
Genome-wide association analysis uncovers rice blast resistance alleles of Ptr and Pia -...
Nature· 6 days agoA GWAS on 500 genetically diverse rice accessions enables identification of an allelic series for the unusual Ptr rice blast resistance gene, and the Pia resistance locus.
High-throughput investigation of stability and Li diffusion of doped solid electrolytes via neural...
Nature· 5 days agoSolid electrolytes hold substantial promise as vital components of all-solid-state batteries. Enhancing their performance necessitates simultaneous improvements in their stability and lithium ...