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In vitro generation of genetic diversity for directed evolution by error-prone artificial DNA...
Nature· 1 day agoError-prone artificial DNA synthesis (epADS) is presented as an effective method for in vitro generation of genetic diversity for directed evolution of various types of genetic parts, synthetic gene circuits and even microbes.
A DNA demethylase reduces seed size by decreasing the DNA methylation of AT-rich transposable...
Nature· 4 days agoA study on a soybean DNA demethylase reveals that seed size is negatively regulated by GmDMEa, which is closely linked to methylation on transposon elements.
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo -...
Nature· 5 days agoUsing primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis, either via genetic ...
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 2 days agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 2 days agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates...
Nature· 5 days agoSkeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 4 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to ...
Flicker electroretinogram in preterm infants - Eye
Nature· 2 days agoInfants born prematurely are at risk of developing retinopathy of prematurity, which is associated with abnormalities in retinal function as measured using electroretinography. The aim of this ...
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy - Cell Death &...
Nature· 2 days agoThe pseudokinase mixed lineage kinase domain-like (MLKL) is an essential component of the activation of the necroptotic pathway. Emerging evidence suggests that MLKL plays a key role in liver ...
Chromatin modifications integrate cis genomic context to instruct transcriptional outputs - Nature...
Nature· 5 days agoBy developing a modular system for precision epigenome editing, we were able to delineate the causal and quantitative role of chromatin modifications in transcription regulation. The precise ...
