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Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel...
Nature· 6 days agoCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were ...
Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 4 days agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Reduced precipitation can induce ecosystem regime shifts in lakes by increasing internal nutrient...
Nature· 5 days agoEutrophication is a main threat to continental aquatic ecosystems. Prevention and amelioration actions have been taken under the assumption of a stable climate, which needs reconsideration.
Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide...
Nature· 4 days agoGenome-wide association study (GWAS) is a powerful tool to identify genomic loci underlying complex traits. However, the application in natural populations comes with challenges, especially ...
Detection of inflammasome activation in liver tissue during the donation process as potential...
Nature· 5 days agoDeceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated ...
Hope for global pandemic treaty rises — despite missed deadline
Nature· 2 days agoDelegates were at an impasse over key issues, but agreements on other public-health emergency...
Unlocking bacterial potential to reduce farmland N2O emissions - Nature
Nature· 6 days agoA study presents a method to mitigate emissions of nitrous oxide from farmland using bacteria to consume nitrous oxide in soil with organic waste as a substrate and vector.
Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing...
Nature· 5 days agoSingle-cell atlas of Microhyla fissipes lungs reveals cell differentiation and functionalization during metamorphosis, further cross-species comparison sheds light vertebrate lung cell type evolution.
Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to...
Nature· 6 days agoDespite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing propionate production from the ...
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial...
Nature· 6 days agoDiabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is characterized by heightened endothelial apoptosis ...