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The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells -...
Nature· 5 days agoThis study reports a unexpected role in endothelial cells (ECs) for PCK2 in proteostasis, independent of its gluconeogenic activity. Perturbation of this role likely contributed to the angiogenic defects observed in ECs with reduced PCK2 levels.
How does exercise help maintain brain health and boost longevity?
Medical News Today· 2 days agoExercise greatly benefits brain health, improving cognition, mood and reducing the risk of...
Ancient viral DNA in the human genome linked to major psychiatric disorders
Medical Xpress· 6 days agoNew research led by King's College London has found that thousands of DNA sequences originating from...
Unlocking blueberry quality: The role of cuticular waxes
Phys.org· 7 days agoCuticular waxes protect fruit by reducing water loss and influencing color. They are a mix of very-long-chain aliphatic and cyclic compounds, varying among fruit species. In blueberries, triterpenoids and β-diketones are most abundant.
A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous...
Nature· 4 days agoE7820 and Indisulam (E7070) are sulfonamide molecular glues that modulate RNA splicing by degrading the splicing factor RBM39 via ternary complex formation with the E3 ligase adaptor DCAF15.
Multiomic analyses uncover immune system response to a heart attack
Medical Xpress· 7 days agoResearchers at LMU University Hospital, Helmholtz Munich and other institutions have now used high-tech biomedical and bioinformatics methods to comprehensively map the immune response to myocardial ...
Sequencing of the developing human brain uncovers hundreds of thousands of new gene transcripts
Medical Xpress· 5 days agoThe research, published in Science, also details how transcript expression varies by cell type and maturity, finding that changing gene-isoform expression levels can help us better understand ...
NeuroBo Pharmaceuticals' DA-1241 in Combination with Semaglutide Improves Liver Fibrosis and...
WRBL Columbus· 6 days agoNeuroBo Pharmaceuticals, Inc. (Nasdaq: NRBO), a clinical-stage biotechnology company focused on the transformation of cardiometabolic diseases, today announced that pre-clinical data suggests ...
New Sequencing Method Jointly Profiles Chromatin Conformation, Transcription in Single Cells
GenomeWeb News· 5 days agoThis story has been updated to include comments from Jian Ma. NEW YORK – Researchers from Carnegie Mellon University and the University of Washington have developed a single-cell assay that ...
Sequencing of the developing human brain uncovers | Newswise
Newswise· 5 days agoA team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain. This novel dataset provides ...