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In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated...
Nature· 6 days agoPartially reprogramming a specific population of neurons in the cerebral cortex of mice, improves cognition through greater activation in memory circuits and plasticity induced by the reorganization of the extracellular matrix.
New Steps Towards a Male Birth Control Pill
US News & World Report· 6 days agoFor decades, the responsibility for birth control has fallen largely on women, but new research suggests a birth control pill for men might one day become a reality. A drug that inhibits STK33 ...
Indoor tanning and eczema: Benefits, risks, and tanning tips
Medical News Today· 1 day agoModerate sun exposure and phototherapy may help improve eczema. Phototherapy uses controlled...
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial...
Nature· 6 days agoRecent studies show that mitochondrial dysfunction is critical for renal tubular cell senescence and kidney aging, and calcium overload and abnormal calcium-dependent kinase
Clinical-stage cancer biotech Actuate latest to eye summer IPO
FierceBiotech· 2 days agoThe second biotech proposition in May seems to suggest the public markets are regaining their...
PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic...
Nature· 2 days agoSplicing factors are frequently mutated in patients with myelodysplastic syndromes and acute myeloid leukaemia. Recent studies have revealed convergent molecular defects caused by splicing factor ...
Study Confirms: No Great Options for Treating VEXAS
MedPage Today· 6 days agoAmong 110 patients in the FRENVEX registry, tumor necrosis factor (TNF) inhibitors were the least effective, with an overall response rate of 15% at 6...
ASCO 2024: Merus touts positive Phase II data for head and neck cancer antibody
Pharmaceutical Technology via Yahoo Finance· 6 days agoOther abstracts coming from the meeting include positive initial results from an ongoing Phase I/II...
Scientists provide novel insights into the effects of high temperature on nutritional obesity
Medical Xpress· 14 hours agoIn contemporary society, obesity has emerged as a worldwide chronic metabolic disorder, imposing substantial burdens on both individual health and health care systems. The insulin resistance ...
KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid...
Nature· 6 days agoInactivated suppressor of mothers against decapentaplegic homolog (SMAD) 4 significantly affects cancer development in pancreatic ductal adenocarcinoma (PDAC). However, the contribution of smad4 ...
