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Detecting the effect of genetic diversity on brain composition in an Alzheimer’s disease mouse model...
Nature· 6 days agoQUINT workflow analysis of cell and amyloid density in AD-BXD mice demonstrates age-dependent and strain-specific increases in gliosis and amyloid accumulation. These changes in brain composition influence age-related variations in gene expression.
Genome-wide association analysis uncovers rice blast resistance alleles of Ptr and Pia -...
Nature· 6 days agoA GWAS on 500 genetically diverse rice accessions enables identification of an allelic series for the unusual Ptr rice blast resistance gene, and the Pia resistance locus.
Chromatin modifications integrate cis genomic context to instruct transcriptional outputs - Nature...
Nature· 6 days agoBy developing a modular system for precision epigenome editing, we were able to delineate the causal and quantitative role of chromatin modifications in transcription regulation. The precise ...
Mechanisms of neuromodulatory volume transmission - Molecular Psychiatry
Nature· 2 days agoA wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs from classical synaptic transmission in important ...
Convergent evolution of fern nectaries facilitated independent recruitment of ant-bodyguards from...
Nature· 2 days agoSome plants use nectar to attract ant bodyguards. Here, the authors use a cross-kingdom phylogenetic approach to find that ferns and angiosperms evolved nectaries in the Cretaceous, coinciding ...
Element from the periodic table’s far reaches coaxed into elusive compound
Nature· 4 days agoChemists achieve synthetic feat with radioactive promethium for the first time.
Enhanced emergent electromagnetic inductance in Tb5Sb3 due to highly disordered helimagnetism -...
Nature· 6 days agoAc current-driven spin motions in helimagnetic metals can generate emergent electric fields acting on conduction electrons, leading to emergent electromagnetic induction (EEMI). In this study ...
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy - Cell Death &...
Nature· 3 days agoThe pseudokinase mixed lineage kinase domain-like (MLKL) is an essential component of the activation of the necroptotic pathway. Emerging evidence suggests that MLKL plays a key role in liver ...
Enhanced quantum coherence of plasmonic resonances with a chiral exceptional points - Communications...
Nature· 4 days agoThe advent of non-Hermitian optics carries new possibilities in manipulating optical response, offering alternative ways to enhance the quantum coherence of plasmonic resonances. Based on a ...
ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish...
Nature· 4 days agoA DADA2 zebrafish model with cecr1b deficiency was generated. Characterization of hematopoietic processes revealed a role of Cecr1b in regulating inflammation and hematopoietic stem cell production through the A2br-mediated adenosine signaling.