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A DNA demethylase reduces seed size by decreasing the DNA methylation of AT-rich transposable...
Nature· 4 days agoA study on a soybean DNA demethylase reveals that seed size is negatively regulated by GmDMEa, which is closely linked to methylation on transposon elements.
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 4 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to ...
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 2 days agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 2 days agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
High-throughput investigation of stability and Li diffusion of doped solid electrolytes via neural...
Nature· 4 days agoSolid electrolytes hold substantial promise as vital components of all-solid-state batteries. Enhancing their performance necessitates simultaneous improvements in their stability and lithium ...
Nonlinear dynamics of femtosecond laser interaction with the central nervous system in zebrafish -...
Nature· 4 days agoWhen a pulsed laser interacts with tissue, the molecules in the sample get excited to a higher energy state and relax either nonradiatively, leading to thermal damage, or via de-excitation processes ...
Construction of TiO2/WO3/TiO2 double heterojunction films for excellent electrochromic performance -...
Nature· 5 days agoElectrochromic devices are applied extensively to camouflages, smart windows, heat insulation layers, and automobile rearview mirrors, etc. The amorphous WO3 is a very attractive electrochromic ...
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy - Cell Death &...
Nature· 2 days agoThe pseudokinase mixed lineage kinase domain-like (MLKL) is an essential component of the activation of the necroptotic pathway. Emerging evidence suggests that MLKL plays a key role in liver ...
Enhanced emergent electromagnetic inductance in Tb5Sb3 due to highly disordered helimagnetism -...
Nature· 5 days agoAc current-driven spin motions in helimagnetic metals can generate emergent electric fields acting on conduction electrons, leading to emergent electromagnetic induction (EEMI). In this study ...
A genome-wide association study identifies a locus associated with knee extension strength in older...
Nature· 5 days agoA genome-wide association study on knee extension strength in 3452 persons of Japanese ancestry 60 years old and above identifies a significant association at a single locus that includes TACC2, a gene encoding a cytoskeleton-related protein.