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Chromatin modifications integrate cis genomic context to instruct transcriptional outputs - Nature...
Nature· 5 days agoBy developing a modular system for precision epigenome editing, we were able to delineate the causal and quantitative role of chromatin modifications in transcription regulation. The precise ...
A genome-wide association study identifies a locus associated with knee extension strength in older...
Nature· 5 days agoA genome-wide association study on knee extension strength in 3452 persons of Japanese ancestry 60 years old and above identifies a significant association at a single locus that includes TACC2, a gene encoding a cytoskeleton-related protein.
Detecting the effect of genetic diversity on brain composition in an Alzheimer’s disease mouse model...
Nature· 5 days agoQUINT workflow analysis of cell and amyloid density in AD-BXD mice demonstrates age-dependent and strain-specific increases in gliosis and amyloid accumulation. These changes in brain composition influence age-related variations in gene expression.
ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish...
Nature· 3 days agoA DADA2 zebrafish model with cecr1b deficiency was generated. Characterization of hematopoietic processes revealed a role of Cecr1b in regulating inflammation and hematopoietic stem cell production through the A2br-mediated adenosine signaling.
Software tools identify forgotten genes
Nature· 22 hours agoFind My Understudied Genes and the Unknome database highlight interesting genes that have been neglected by science.
Author Correction: Single-cell transcriptomics reveal extracellular vesicles secretion with a...
Nature· 2 days agoCorrection to: Communications
Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1...
Nature· 7 days agoBrain endothelial cells activate EGFR signaling in triple-negative breast cancer cells, promoting brain metastasis. DOCK4 is crucial for cancer cell extravasation to the brain, with EGFR activation driving cell elongation reversed by Afatinib.
Author Correction: Optimized model architectures for deep learning on genomic data - Communications...
Nature· 2 days agoCorrection to: Communications
Edge sites dominate the hydrogen evolution reaction on platinum nanocatalysts - Nature Catalysis
Nature· 3 days agoPt is the most active catalyst for the hydrogen evolution reaction in acidic media, but the precise nature of its active sites remains elusive. Now electrical transport spectroscopy and molecular ...
Ozempic keeps wowing: trial data show benefits for kidney disease
Nature· 1 day agoSemaglutide, the same compound in obesity drug Wegovy, slashes risk of kidney failure and death for...