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A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous...
Nature· 5 days agoE7820 and Indisulam (E7070) are sulfonamide molecular glues that modulate RNA splicing by degrading the splicing factor RBM39 via ternary complex formation with the E3 ligase adaptor DCAF15.
JD Supra: OFCCP Week in Review Special Edition
JD Supra· 3 days agoIn legal terms, employees are “similarly situated” only if they share all the same “essential elements” of the job they perform, John said. “This is something I run into all the time,” Candee ...
CMR provides comparable measurements of diastolic function as echocardiography - Scientific Reports
Nature· 7 days agoClinical application of cardiac magnetic resonance (CMR) is expanding but CMR assessment of LV diastolic function is still being validated. The purpose of this study was to validate assessments ...
Accelerated Approval Process Is Not Without Risk: Placing Recent FDA Action in Context | JD Supra
JD Supra· 1 day agoOn February 23, the Food and Drug Administration (FDA) withdrew approval of Pepaxto (melphalan flufenamide), a drug that it had previously granted accelerated approval for treatment of multiple ...
FAU Experts for the 2024 Hurricane Season | Newswise
Newswise· 6 days agoThe 2024 Atlantic hurricane season begins on June 1, and forecasts indicate a highly active season. Anthony Abbate is a professor and director of the...
Utility of TTR-INR guided warfarin adjustment protocol to improve time in therapeutic range in...
Nature· 7 days agoWarfarin remains the most prescribed oral anticoagulant of choice in atrial fibrillation (AF) patient in resource-limited settings. Despite evidence linking Time in Therapeutic Range (TTR) to ...
Humidity-tolerant porous polymer coating for passive daytime radiative cooling - Nature...
Nature· 4 days agoIn order to realize daytime radiative cooling, high solar reflectance (Rsolar) and thermal emittance in the atmospheric transmission window (ε8-13) are essential to achieve absorbed solar energy ...
Review: 'Combee' delves into Harriet Tubman's work in SC and the Port Royal Experiment
The Post and Courier· 3 days agoIn 'Combee,' Edda Fields-Black pens history of Harriet Tubman's efforts in the Beaufort area of...
JD Supra: Appraisal Bias Settlement: Potential Roadmap
JD Supra· 2 days agoThe lender and consumers reached a settlement in an appraisal bias case, Nathan Connolly and Shani Mott v. Shane Lanham, 20/20 Valuations, LLC, and loanDepot.com, LLC, filed in Maryland District ...
Fed's Susan Collins sees inflation steadily coming down
Axios· 6 days agoOn Tuesday afternoon, Axios spoke with Susan M. Collins, the president of the Federal Reserve Bank...
