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Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 5 days agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to...
Nature· 4 days agoCaspase-8 (Casp8) serves as an initiator of apoptosis or a suppressor of necroptosis in context-dependent manner. Members of the p90 RSK family can phosphorylate caspase-8 at threonine-265 ( ...
Los Angeles Angels Schedule, Live Scores & Results - MLB 2024
Covers.com· 6 days agoStay Up-To-Date With The Latest Los Angeles Angels Schedule, Live Scores, And Results For The 2024 MLB Season!
Melatonin alleviates septic ARDS by inhibiting NCOA4-mediated ferritinophagy in alveolar macrophages...
Nature· 4 days agoMelatonin (MT), an endogenous neurohormone, has antioxidant and anti-inflammatory effects and can reduce septic ARDS. However, it is not clear whether MT’s pulmonary protective ...
Horatio Alger Association to Sponsor PBS' Annual National Memorial Day Concert for Fourth...
PRWeb· 6 days ago/PRNewswire-PRWeb/ -- Horatio Alger Association of Distinguished Americans, Inc., a nonprofit educational organization honoring the achievements of outstanding...
Va. teacher pay gets a boost in budget, but it’s still projected to fall short of national average
Loudoun Times-Mirror· 6 days agoLegislation that would have aligned Virginia teachers’ pay with the national average or higher by...
Exploring the pathways of drug repurposing and Panax ginseng treatment mechanisms in chronic heart...
Nature· 1 day agoChronic Heart Failure (CHF) is a significant global public health issue, with high mortality and morbidity rates and associated costs. Disease modules, which are collections of disease-related ...
Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis...
Nature· 1 day agoCancer stem cells (CSCs) are a sub-population of cells possessing high tumorigenic potential, which contribute to therapeutic resistance, metastasis and recurrence. Eradication of CSCs is widely ...
Astros vs Mariners Match Player Stats - May 27, 2024
Covers.com· 6 hours agoHouston Astros vs Seattle Mariners MLB game box score for May 27, 2024.
Survival dynamics of starving bacteria are determined by ion homeostasis that maintains plasmolysis...
Nature· 5 days agoWhen bacteria starve, their cytoplasm detaches from the cell wall. A model now shows that this process determines bacterial death rates and can be controlled to keep bacteria viable in a starved state.