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Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1...
Nature· 7 days agoBrain endothelial cells activate EGFR signaling in triple-negative breast cancer cells, promoting brain metastasis. DOCK4 is crucial for cancer cell extravasation to the brain, with EGFR activation driving cell elongation reversed by Afatinib.
A genome-wide association study identifies a locus associated with knee extension strength in older...
Nature· 5 days agoA genome-wide association study on knee extension strength in 3452 persons of Japanese ancestry 60 years old and above identifies a significant association at a single locus that includes TACC2, a gene encoding a cytoskeleton-related protein.
Genome-wide association analysis uncovers rice blast resistance alleles of Ptr and Pia -...
Nature· 5 days agoA GWAS on 500 genetically diverse rice accessions enables identification of an allelic series for the unusual Ptr rice blast resistance gene, and the Pia resistance locus.
ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish...
Nature· 3 days agoA DADA2 zebrafish model with cecr1b deficiency was generated. Characterization of hematopoietic processes revealed a role of Cecr1b in regulating inflammation and hematopoietic stem cell production through the A2br-mediated adenosine signaling.
Author Correction: Optimized model architectures for deep learning on genomic data - Communications...
Nature· 2 days agoCorrection to: Communications
Element from the periodic table’s far reaches coaxed into elusive compound
Nature· 3 days agoChemists achieve synthetic feat with radioactive promethium for the first time.
Author Correction: Single-cell transcriptomics reveal extracellular vesicles secretion with a...
Nature· 2 days agoCorrection to: Communications
China's Yangtze fish-rescue plan is a failure, study says
Nature· 5 days agoResearchers have debated the best management plan for highly endangered fish species since the...
These crows have counting skills previously only seen in people
Nature· 2 days agoThe corvids are the first animals other than humans known to produce a deliberate number of calls on...
Chromatin modifications integrate cis genomic context to instruct transcriptional outputs - Nature...
Nature· 5 days agoBy developing a modular system for precision epigenome editing, we were able to delineate the causal and quantitative role of chromatin modifications in transcription regulation. The precise ...