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Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo - Molecular...
Nature· 6 days agoAutism Spectrum Disorders (ASD) comprise a range of early age-onset neurodevelopment disorders with genetic heterogeneity. Most ASD related genes are involved in synaptic function, which is ...
Detecting the effect of genetic diversity on brain composition in an Alzheimer’s disease mouse model...
Nature· 4 days agoQUINT workflow analysis of cell and amyloid density in AD-BXD mice demonstrates age-dependent and strain-specific increases in gliosis and amyloid accumulation. These changes in brain composition influence age-related variations in gene expression.
A genome-wide association study identifies a locus associated with knee extension strength in older...
Nature· 4 days agoA genome-wide association study on knee extension strength in 3452 persons of Japanese ancestry 60 years old and above identifies a significant association at a single locus that includes TACC2, a gene encoding a cytoskeleton-related protein.
A systematic synthesis and analysis of English-language Shuōwén scholarship - Humanities and Social...
Nature· 7 days agoThis study adopts the systematic literature review as the research design. The systematic literature review uses systematic, explicit and reproducible methodology to identify, evaluate and synthesize ...
Guidelines for academics aim to lessen ethical pitfalls in generative-AI use
Nature· 2 days agoResearchers warn against normalizing the use of AI without safeguarding against risks.
Chromatin modifications integrate cis genomic context to instruct transcriptional outputs - Nature...
Nature· 4 days agoBy developing a modular system for precision epigenome editing, we were able to delineate the causal and quantitative role of chromatin modifications in transcription regulation. The precise ...
Promethium bound: fundamental chemistry of an elusive element finally observed
Nature· 2 days agoThe preparation and analysis of a complex of promethium.
Can mathematicians help to solve social-justice problems?
Nature· 2 days agoResearchers discuss the triumphs and trials of using their craft to tackle society’s greatest...
China's Yangtze fish-rescue plan is a failure, study says
Nature· 4 days agoResearchers have debated the best management plan for highly endangered fish species since the...
What’s behind Britain’s earthworm cataclysm?
The Economist· 1 day agoCharles Darwin liked an earthworm. What earthworms felt about Charles Darwin is less clear. Darwin recorded all this somewhat apologetically. On Google ...