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Fluorescent fatty acid conjugates for live cell imaging of peroxisomes - Nature Communications
Nature· 5 days agoThe array of tools to image peroxisome regulation is still limited. Here, the authors develop improved fatty acid-based probes with high peroxisome specificity and bright fluorescence in the ...
Nonlinear dynamics of femtosecond laser interaction with the central nervous system in zebrafish -...
Nature· 5 days agoWhen a pulsed laser interacts with tissue, the molecules in the sample get excited to a higher energy state and relax either nonradiatively, leading to thermal damage, or via de-excitation processes ...
New Sequencing Method Jointly Profiles Chromatin Conformation, Transcription in Single Cells
GenomeWeb News· 2 days agoThis story has been updated to include comments from Jian Ma. NEW YORK – Researchers from Carnegie Mellon University and the University of Washington have developed a single-cell assay that ...
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo -...
Nature· 6 days agoUsing primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis ...
KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid...
Nature· 2 days agoInactivated suppressor of mothers against decapentaplegic homolog (SMAD) 4 significantly affects cancer development in pancreatic ductal adenocarcinoma (PDAC). However, the contribution of smad4 ...
Keeping CAR T Cells Sharp
The Scientist· 5 days agoChimeric antigen receptor (CAR) T cells have a tough job. Engineered with a receptor that recognizes molecules decorating the surface of cancer cells,...
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 5 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to ...
Survival dynamics of starving bacteria are determined by ion homeostasis that maintains plasmolysis...
Nature· 3 days agoWhen bacteria starve, their cytoplasm detaches from the cell wall. A model now shows that this process determines bacterial death rates and can be controlled to keep bacteria viable in a starved state.
Lipid nanoparticle-mRNA regimen reverses inflammation and aids recovery from diabetic wounds in mice
Phys.org· 5 days agoDetails on their findings were published in a paper titled "Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation" in the May 20 online issue of the Proceedings ...
Here's how Nightdive "brought the horror back to System Shock" in its remake of the sci-fi FPS...
Games Radar· 3 days agoNightdive is a studio on a noble mission: sourcing the rights to forgotten retro games, reformatting...