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The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells -...
Nature· 5 days agoThis study reports a unexpected role in endothelial cells (ECs) for PCK2 in proteostasis, independent of its gluconeogenic activity. Perturbation of this role likely contributed to the angiogenic defects observed in ECs with reduced PCK2 levels.
Simple New Strategy Improves Safety and Precision of CRISPR Gene Editing
SciTechDaily· 2 days agoKAUST researchers have improved CRISPR gene editing safety by reducing harmful DNA deletions and...
Reanalysis of genomic data in rare disease: current practice and attitudes among Australian clinical...
Nature· 3 days agoReanalyzing stored genomic data over time is highly effective in increasing diagnostic yield in rare disease. Automation holds the promise of delivering the benefits of reanalysis at scale.
Tardigrade secretory proteins protect biological structures from desiccation - Communications...
Nature· 3 days agoR. varieornatus is the most desiccation-resistant tardigrade and is well-characterized; a draft genome sequence is available, and crystal structures of two SAHS proteins from ...
Genetic mutation responsible for new coat pattern in cats in Finland identified
Phys.org· 5 days agoIn their study, published in the journal Animal Genetics, the group sequenced the genomes of two of...
Man finds ancient mammoth bones in his wine cellar
CBS News via Yahoo News· 3 days agoAndreas Pernerstorfer was renovating his wine cellar in Gobelsburg, Austria, when he made an astounding ancient discovery. It wasn't vintage wine — it...
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative...
Nature· 3 days agoDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets. Spliceosome-related genes were significantly altered in HCC. Oncofetal ...
Author Correction: Developmental origins shape the paediatric cancer genome - Nature Reviews Cancer
Nature· 7 days agoCorrection to: Nature Reviews Cancer https://doi.org/10.1038/s41568-024-00684-9, published online 2 May 2024In the version of the article initially published, in the second paragraph of the ...
New Study Investigates Why More Black Woman Are Diagnosed With Breast Cancer
Black Enterprise· 5 days agoResearchers launched a new study to find the reasoning behind a rise in Black women being diagnosed...
Scientists made mice with Y chromosomes female by deleting just 6 tiny molecules
Live Science· 5 days agoScientists know a great deal about the genes involved in making the proteins needed for these...