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Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis...
Nature· 23 hours agoHere, we show that the lysosomal cation channel TRPML1 represents a promising target for CSCs. TRPML1 is highly expressed in breast cancer cells and exhibits ...
Luton man treated for breast cancer given 'wonder drug'
BBC News· 1 day agoA man who was given "a wonder drug" to target his stage four cancer said it was "like an oasis in...
Anti-Cancer Drug Pembrolizumab: Frequently Used Alone Or With Other Treatments
Forbes· 1 day agoPembrolizumab, sold as Keytruda by Merck & Co., was one of the first inhibitors to hit the market. A...
Nuclear receptors — studying genes to understand hormones - Nature Reviews Genetics
Nature· 6 days agoLigand-bound receptors undergo conformational changes to facilitate binding both to DNA and to co-factors that facilitate interactions with chromatin and core transcriptional ...
Mirat Shah, MD, on Elacestrant's FDA Approval for Breast Cancer With ESR1 Mutations
MedPage Today· 7 days agoFDA scientists published a detailed rationale for the approval of elacestrant (Orserdu), the first...
Edgewood Oncology treats first two subjects in breast cancer trial
Clinical Trials Arena via Yahoo Finance· 6 days agoThe multicentre, open-label, nonrandomised, multiple dose study is designed...resistance to these...
Small Business - Shelby County Reporter | Shelby County Reporter
The Shelby County Reporter· 4 days agoBlueprint Medicines to Present the First Promising and Most Advanced Clinical Data for a CDK2 Inhibitor in Combination with an Approved CDK4/6 Inhibitor in HR+/HER2- Breast
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 7 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical ...
Eisai Showcases Oncology Portfolio and Pipeline at ASCO 2024
FOX 23 News Albany· 5 days agoEisai announced today the presentation of research across multiple types of cancer from its oncology portfolio and pipeline during the 2024 American Society of Clinical...
Anixa Biosciences Commences Treatment of Fifth Patient in Ovarian Cancer CAR-T Clinical Trial
FOX 23 News Albany· 7 days agoThe study is being conducted through a research partnership with Moffitt Cancer Center.