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The Next Humira? Insmed Catapults 119% On Its 'Very Attractive' Opportunity In Lung Disease.
Investor's Business Daily· 20 hours ago"While some may wonder about the lack of dose response, we do not believe it is necessary,"...
PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors
Medical Xpress· 5 days agoA new editorial paper was published in Oncoscience, titled "PH-binding motifs as a platform for drug design: Lessons from protease-activated receptors; PARs."
Repurposed protease controls important signaling molecule-activating protein
Phys.org· 7 days agoThis process involves ADAM17 cleaving (shedding) the signaling molecules from their precursor forms...
The gluconeogenesis enzyme PCK2 has a non-enzymatic role in proteostasis in endothelial cells -...
Nature· 6 days agoThis study reports a unexpected role in endothelial cells (ECs) for PCK2 in proteostasis, independent of its gluconeogenic activity. Perturbation of this role likely contributed to the angiogenic defects observed in ECs with reduced PCK2 levels.
Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive...
Nature· 6 days agoPlectasin, a natural host defence peptide of fungal origin, uses a calcium-sensitive supramolecular killing mechanism to block bacterial cell wall synthesis.
Tango terminates USP1 inhibitor programme
Clinical Trials Arena via Yahoo Finance· 5 days agoTNG348 is an inhibitor of the ubiquitin-specific protease 1 (USP1) enzyme, which regulates DNA damage response. Inhibiting USP1 can impact the repair...
Foldamers controlled by functional triamino acids: structural investigation of α/γ-hybrid...
Nature· 4 days agoPeptide-like foldamers are known to be controlled by amide backbone hydrogen bonding, however, the influence of functional groups forming individual hydrogen-bond networks remains underexplored ...
Tardigrade secretory proteins protect biological structures from desiccation - Communications...
Nature· 4 days agoR. varieornatus is the most desiccation-resistant tardigrade and is well-characterized; a draft genome sequence is available, and crystal structures of two SAHS proteins from this organism have ...
Medivir´s licensee, Tango Therapeutics, has discontinued development of its TNG348 clinical program
WTRF Wheeling· 6 days agoTNG348 is a novel USP1 (ubiquitin-specific protease 1) inhibitor, for the treatment of BRCA1/2-mutant and other homologous recombination deficiency (HRD)+ cancers, and has ...
BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) Stock Position Reduced by Swiss National Bank
ETF DAILY NEWS· 5 days agoSwiss National Bank trimmed its position in BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX – Free Report) by 10.1% in the fourth quarter, according to its most recent 13F filing with the Securities ...
