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Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 19 hours agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
Author Correction: Optimized model architectures for deep learning on genomic data - Communications...
Nature· 19 hours agoCorrection to: Communications
Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 19 hours agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
Author Correction: Single-cell transcriptomics reveal extracellular vesicles secretion with a...
Nature· 19 hours agoCorrection to: Communications
Unveiling the electronic origin of lanthanide based Metal Organic Framework with ideal spin...
Nature· 7 days agoRecently ideal spin filtering ability was demonstrated in the Dy-L-Tar metal-organic framework. In this work the authors show that this unusual effect emerges from the asymmetric display of ...
TBC9, an essential TBC-domain protein, regulates early vesicular transport and IMC formation in...
Nature· 6 days agoA study suggests that TBC9, one of the Rab GTPase Activating Proteins, is crucial for early vesicular transport and inner membrane complex formation by regulating Rab2, Rab11A and Rab11B in Toxoplasma gondii.
Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea...
Nature· 6 days agoWe analyzed the organ of Corti motions, component by component. Outer hair cells exploit their supporting cells to boost vibrations of the upper part of the organ of Corti while minimally disturbing the basilar membrane.
Multidrug-resistant phenotypes of genetically diverse Escherichia coli isolates from healthy...
Nature· 7 days agoΒ-lactamases-producing Escherichia coli are a widely distributed source of antimicrobial resistance (AMR), for animals and humans. Little is known about the sensitivity profile and genetic characteristics ...
A DNA demethylase reduces seed size by decreasing the DNA methylation of AT-rich transposable...
Nature· 3 days agoA study on a soybean DNA demethylase reveals that seed size is negatively regulated by GmDMEa, which is closely linked to methylation on transposon elements.
Large anomalous Hall conductivity induced by spin chirality fluctuation in an ultraclean frustrated...
Nature· 3 days agoMagnetic frustration of spins often leads to nontrivial spin textures and anomalous Hall responses, but typically below the magnetic transition temperature. The authors observe a giant unconventional ...