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Multiple environmental stressors affect predation pressure in a tropical freshwater system -...
Nature· 18 hours agoField observations show that fish predators exhibit stronger association with warmer, still, clear waters. Here they exert heightened predation pressure on prey fish, highlighting the importance of ecological context in predator-prey dynamics.
PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic...
Nature· 2 days agoSplicing factors are frequently mutated in patients with myelodysplastic syndromes and acute myeloid leukaemia. Recent studies have revealed convergent molecular defects caused by splicing factor ...
Unlocking bacterial potential to reduce farmland N2O emissions - Nature
Nature· 18 hours agoA study presents a method to mitigate emissions of nitrous oxide from farmland using bacteria to consume nitrous oxide in soil with organic waste as a substrate and vector.
Transgene removal using an in cis programmed homing endonuclease via single-strand annealing in the...
Nature· 18 hours agoThis study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
How antibody–drug conjugates aim to take down cancer
Nature· 1 day agoScientists are trying to work out how to balance potency with toxicity and tackle the cost of next-generation therapeutics.
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial...
Nature· 18 hours agoDiabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is characterized by heightened endothelial apoptosis ...
Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to...
Nature· 18 hours agoDespite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing propionate production from the ...
Retraction Note: CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7 - Cell...
Nature· 18 hours agoRetraction to: Cell
Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 7 days agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative...
Nature· 5 days agoDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets. Spliceosome-related genes were significantly altered in HCC. Oncofetal ...