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Multiple omics levels of chronic lymphocytic leukemia - Cell Death Discovery
Nature· 1 day agoChronic lymphocytic leukemia (CLL) is a lymphoproliferative malignancy characterized by the proliferation of functionally mature but incompetent B cells. It is the most prevalent type of leukemia ...
Why museums should repatriate fossils
Nature· 4 days agoThe legacy of a palaeontology expedition into Native American lands 150 years ago should prompt a rethink of where and how fossil collections are...
Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer...
Nature· 5 days agoAging-related cancer incidence remains not fully understood. Here, the authors depict a progressive process of senescence in murine mammary stem cells at single-cell resolution, which is governed ...
hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under...
Nature· 3 days agoMitochondrial homeostasis is coordinated through communication between mitochondria and the nucleus. In response to stress, mitochondria generate retrograde signals to protect against their ...
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia -...
Nature· 2 days agoPRMT2 is a key regulator of inflammation in acute myeloid leukemia. PRMT2-deficient cells exhibit a pro-inflammatory profile associated with STAT3 activation.
Structural basis of tolvaptan binding to the vasopressin V2 receptor - Acta Pharmacologica Sinica
Nature· 2 days agoThe vasopressin V2 receptor (V2R) is a validated therapeutic target for autosomal dominant polycystic kidney disease (ADPKD), with tolvaptan being the first FDA-approved antagonist. Herein, ...
Gigantic oddball aurora seen from Earth for the first time
Nature· 1 day agoA camera captured the vast, diffuse glow produced after the solar wind dropped to a whisper.
Direct radical functionalization of native sugars - Nature
Nature· 3 days agoA radical-based method for functionalizing native sugars shows a way to remove typical protecting-group manipulations.
Key driver of inflammatory bowel disease identified
Nature· 1 day agoIn-depth analysis of a suspect genomic region revealed a key driver of IBD and other autoimmune conditions — as well as druggable targets.
Could rats and dogs detect disease better than the finest lab equipment?
Nature· 3 days agoThe animals’ keen sense of smell could improve the detection of illnesses such as cancer and...