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A DNA demethylase reduces seed size by decreasing the DNA methylation of AT-rich transposable...
Nature· 6 days agoA study on a soybean DNA demethylase reveals that seed size is negatively regulated by GmDMEa, which is closely linked to methylation on transposon elements.
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 6 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to ...
Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 4 days agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative...
Nature· 2 days agoDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets. Spliceosome-related genes were significantly altered in HCC. Oncofetal ...
Higher surface folding of the human premotor cortex is associated with better long-term learning...
Nature· 2 days agoA brain imaging study shows that humans with more complex cortical folds in a premotor brain region have a higher capacity to learn a challenging new motor skill during six weeks of practice.
Bio-stimulating effect of endophytic Aspergillus flavus AUMC 16068 and its respective...
Nature· 2 days agoHeavy metal accumulation is one of the major agronomic challenges that has seriously threatened food safety. As a result, metal-induced phytotoxicity concerns require quick and urgent action ...
Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial...
Nature· 3 days agoRenal tubular epithelial cell senescence plays a critical role in promoting and accelerating kidney aging and age-related renal fibrosis. Senescent cells not only lose their self-repair ability ...
In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated...
Nature· 3 days agoPartially reprogramming a specific population of neurons in the cerebral cortex of mice, improves cognition through greater activation in memory circuits and plasticity induced by the reorganization of the extracellular matrix.
GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates...
Nature· 7 days agoSkeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
ADA2 regulates inflammation and hematopoietic stem cell emergence via the A2bR pathway in zebrafish...
Nature· 5 days agoA DADA2 zebrafish model with cecr1b deficiency was generated. Characterization of hematopoietic processes revealed a role of Cecr1b in regulating inflammation and hematopoietic stem cell production through the A2br-mediated adenosine signaling.