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Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel...
Nature· 7 days agoCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were ...
Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny...
Nature· 5 days agoAutism spectrum disorders (ASDs) are known to present sex-specific differences. At the same time, understanding how maternal behaviours are affected by pathogenic mutations is crucial to translate ...
Unlocking bacterial potential to reduce farmland N2O emissions - Nature
Nature· 7 days agoA study presents a method to mitigate emissions of nitrous oxide from farmland using bacteria to consume nitrous oxide in soil with organic waste as a substrate and vector.
Preparation of thiourea derivative incorporated Ag3PO4 core shell for enhancement of photocatalytic...
Nature· 2 days agoPhotocatalysis is a promising technique to reduce hazardous organic pollutants using semiconductors under visible light. However, previous studies have been concerned with the behavior of silver ...
Hexanucleotide repeat expansion in SCA36 reduces the expression of genes involved in ribosome...
Nature· 7 days agoHereditary spinocerebellar ataxia (SCA) is a group of clinically and genetically heterogeneous inherited disorders characterized by slowly progressive cerebellar ataxia. We ascertained a Japanese ...
Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 5 days agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Reduced precipitation can induce ecosystem regime shifts in lakes by increasing internal nutrient...
Nature· 6 days agoEutrophication is a main threat to continental aquatic ecosystems. Prevention and amelioration actions have been taken under the assumption of a stable climate, which needs reconsideration.
Detection of inflammasome activation in liver tissue during the donation process as potential...
Nature· 6 days agoDeceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated ...
Transgene removal using an in cis programmed homing endonuclease via single-strand annealing in the...
Nature· 7 days agoThis study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability - Molecular...
Nature· 6 days agoAs the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor (SSRI) class represent prime candidates for drug ...