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Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 7 hours agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny...
Nature· 10 hours agoAutism spectrum disorders (ASDs) are known to present sex-specific differences. At the same time, understanding how maternal behaviours are affected by pathogenic mutations is crucial to translate ...
Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability - Molecular...
Nature· 1 day agoAs the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor (SSRI) class represent prime candidates for drug ...
Detection of inflammasome activation in liver tissue during the donation process as potential...
Nature· 1 day agoDeceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated ...
Reduced precipitation can induce ecosystem regime shifts in lakes by increasing internal nutrient...
Nature· 1 day agoEutrophication is a main threat to continental aquatic ecosystems. Prevention and amelioration actions have been taken under the assumption of a stable climate, which needs reconsideration.
Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing...
Nature· 1 day agoSingle-cell atlas of Microhyla fissipes lungs reveals cell differentiation and functionalization during metamorphosis, further cross-species comparison sheds light vertebrate lung cell type evolution.
What is science? Tech heavyweights brawl over definition
Nature· 14 hours agoAI pioneer Yann LeCun and Elon Musk went head-to-head in a debate about modern research that drew...
Author Correction: Forecasting the ecological footprint of G20 countries in the next 30 years -...
Nature· 7 hours agoThe Funding section in the original version of this Article was omitted. “The University of Sheffield Institutional Open Access Fund supported the Open Access of this paper.” The original Article has been corrected.
Designing reversible anticoagulants
Nature· 7 hours agoDiscover the world’s best science and medicine | Nature.com
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative...
Nature· 6 days agoDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets. Spliceosome-related genes were significantly altered in HCC. Oncofetal ...