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MDMA therapy for PTSD rejected by FDA panel
Nature· 2 hours agoScientific advisors vote overwhelmingly that the risks of MDMA treatment for post-traumatic stress disorder outweigh the benefits.
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel...
Nature· 7 days agoCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were ...
Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide...
Nature· 5 days agoGenome-wide association study (GWAS) is a powerful tool to identify genomic loci underlying complex traits. However, the application in natural populations comes with challenges, especially ...
Cryo-EM structure of cadmium-bound human ABCB6 - Communications Biology
Nature· 5 days agoCryo-EM structure of human ATP-binding cassette transporter 6 (ABCB6) in complex with Cd(II) and glutathione (GSH) provides molecular insight into its dual role, essential for heme biosynthesis and as a heavy metal efflux pump.
Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny...
Nature· 5 days agoAutism spectrum disorders (ASDs) are known to present sex-specific differences. At the same time, understanding how maternal behaviours are affected by pathogenic mutations is crucial to translate ...
Hexanucleotide repeat expansion in SCA36 reduces the expression of genes involved in ribosome...
Nature· 7 days agoHereditary spinocerebellar ataxia (SCA) is a group of clinically and genetically heterogeneous inherited disorders characterized by slowly progressive cerebellar ataxia. We ascertained a Japanese ...
Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability - Molecular...
Nature· 6 days agoAs the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor (SSRI) class represent prime candidates for drug ...
Preparation of thiourea derivative incorporated Ag3PO4 core shell for enhancement of photocatalytic...
Nature· 2 days agoPhotocatalysis is a promising technique to reduce hazardous organic pollutants using semiconductors under visible light. However, previous studies have been concerned with the behavior of silver ...
Modulation of histone acetylation enables fully mechanized hybrid rice breeding - Nature Plants
Nature· 2 days agoThe manual-labour-intensive hybrid seed production process is a limiting step for fully mechanized hybrid rice breeding. This work demonstrates that the use of ideal small-grain alleles of GSE3 enables fully mechanized hybrid rice breeding.
Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 5 days agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.