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Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are...
Nature· 10 hours agoDespite extensive characterisation of uropathogenic Escherichia coli (UPEC) causing urinary tract infections (UTIs), the genetic background of non-urinary extraintestinal pathogenic E. coli ...
Convergent evolution of fern nectaries facilitated independent recruitment of ant-bodyguards from...
Nature· 10 hours agoSome plants use nectar to attract ant bodyguards. Here, the authors use a cross-kingdom phylogenetic approach to find that ferns and angiosperms evolved nectaries in the Cretaceous, coinciding ...
Lab-grown sperm and eggs: ‘epigenetic’ reset in human cells paves the way
Nature· 4 days agoTechnique wipes away tags on DNA that must be reprogrammed during development of reproductive cells.
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 1 day agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
Ozempic keeps wowing: trial data show benefits for kidney disease
Nature· 17 hours agoSemaglutide, the same compound in obesity drug Wegovy, slashes risk of kidney failure and death for...
Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 1 day agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
Software tools identify forgotten genes
Nature· 10 hours agoFind My Understudied Genes and the Unknome database highlight interesting genes that have been neglected by science.
Flicker electroretinogram in preterm infants - Eye
Nature· 1 day agoInfants born prematurely are at risk of developing retinopathy of prematurity, which is associated with abnormalities in retinal function as measured using electroretinography. The aim of this ...
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo -...
Nature· 4 days agoUsing primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis, either via genetic ...
TBC9, an essential TBC-domain protein, regulates early vesicular transport and IMC formation in...
Nature· 6 days agoA study suggests that TBC9, one of the Rab GTPase Activating Proteins, is crucial for early vesicular transport and inner membrane complex formation by regulating Rab2, Rab11A and Rab11B in Toxoplasma gondii.
