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Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 16 hours agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
Instability could explain the Sun’s curious cycle
Nature· 2 days agoThe solar magnetic field could be driven by a near-surface effect.
TBC9, an essential TBC-domain protein, regulates early vesicular transport and IMC formation in...
Nature· 6 days agoA study suggests that TBC9, one of the Rab GTPase Activating Proteins, is crucial for early vesicular transport and inner membrane complex formation by regulating Rab2, Rab11A and Rab11B in Toxoplasma gondii.
Unveiling the electronic origin of lanthanide based Metal Organic Framework with ideal spin...
Nature· 7 days agoRecently ideal spin filtering ability was demonstrated in the Dy-L-Tar metal-organic framework. In this work the authors show that this unusual effect emerges from the asymmetric display of ...
A meshless computational framework for studying cold spray additive manufacturing including large...
Nature· 6 days agoCold spray (CS) has emerged as an appealing additive manufacturing (AM) technique for producing or repairing individual components or entire structures. Compared to fusion-based AM technologies ...
A DNA demethylase reduces seed size by decreasing the DNA methylation of AT-rich transposable...
Nature· 3 days agoA study on a soybean DNA demethylase reveals that seed size is negatively regulated by GmDMEa, which is closely linked to methylation on transposon elements.
Large anomalous Hall conductivity induced by spin chirality fluctuation in an ultraclean frustrated...
Nature· 3 days agoMagnetic frustration of spins often leads to nontrivial spin textures and anomalous Hall responses, but typically below the magnetic transition temperature. The authors observe a giant unconventional ...
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 3 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to ...
GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates...
Nature· 4 days agoSkeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
Author Correction: Amyloid modifier SERF1a interacts with polyQ-expanded huntingtin-exon 1 via...
Nature· 6 days agoCorrection to: Communications