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DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression -...
Nature· 22 hours agoType 1 insulin-like growth factor receptor (IGF1R) plays an important role in cancer, however, posttranscriptional regulation such as N6-methyladenosine (m6A) of IGF1R remains unclear. Here, ...
Transgene removal using an in cis programmed homing endonuclease via single-strand annealing in the...
Nature· 22 hours agoThis study demonstrates that inserted transgene sequences in the Aedes aegypti genome can be pre-programmed to remove themselves and restore a formerly disrupted target gene through the in cis activity of homing endonucleases.
Unlocking bacterial potential to reduce farmland N2O emissions - Nature
Nature· 22 hours agoA study presents a method to mitigate emissions of nitrous oxide from farmland using bacteria to consume nitrous oxide in soil with organic waste as a substrate and vector.
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial...
Nature· 22 hours agoDiabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is characterized by heightened endothelial apoptosis ...
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel...
Nature· 22 hours agoCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were ...
Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to...
Nature· 22 hours agoDespite prior concerns regarding potential adverse effects, a 23-h fasting regimen mitigates metabolic abnormalities observed in Pcca-mutated mice by reducing propionate production from the ...
Multiple environmental stressors affect predation pressure in a tropical freshwater system -...
Nature· 22 hours agoField observations show that fish predators exhibit stronger association with warmer, still, clear waters. Here they exert heightened predation pressure on prey fish, highlighting the importance of ecological context in predator-prey dynamics.
Retraction Note: CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7 - Cell...
Nature· 22 hours agoRetraction to: Cell
Advances in highly targeted radiation treatment for cancer have ignited interest in a once obscure...
Nature· 1 day agoTherapies that treat while diagnosing — theranostics — can extend length of survival and improve the...
PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic...
Nature· 2 days agoSplicing factors are frequently mutated in patients with myelodysplastic syndromes and acute myeloid leukaemia. Recent studies have revealed convergent molecular defects caused by splicing factor ...