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Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis...
Nature· 15 hours agoCancer stem cells (CSCs) are a sub-population of cells possessing high tumorigenic potential, which contribute to therapeutic resistance, metastasis and recurrence. Eradication of CSCs is widely ...
Multi-wall carbon Nanotube surface-based functional nanoparticles for stimuli-responsive dual...
Nature· 15 hours agoCarbon nanotubes (CNTs) have the potential to serve as delivery systems for medicinal substances and gene treatments, particularly in cancer treatment. Co-delivery of curcumin (CUR) and Methotrexate ...
Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of...
Nature· 15 hours agoThe role of circular RNAs (circRNAs) in glucose metabolism in pancreatic duct adenocarcinoma (PDAC) remains elusive. Through RNA sequencing of cells cultured under conditions of glucose deprivation ...
Agricultural drought-driven mechanism of coupled climate and human activities in the karst basin of...
Nature· 15 hours agoTimely and accurate agricultural drought monitoring and drought-driven mechanism analysis in karst basins in the context of global warming are highly important for drought disaster monitoring ...
Exploring the pathways of drug repurposing and Panax ginseng treatment mechanisms in chronic heart...
Nature· 15 hours agoChronic Heart Failure (CHF) is a significant global public health issue, with high mortality and morbidity rates and associated costs. Disease modules, which are collections of disease-related ...
India is trialing gene-edited rice after regulatory change
Nature· 4 days agoPublic sector labs are testing genetic tweaks for improved crops
A DNA demethylase reduces seed size by decreasing the DNA methylation of AT-rich transposable...
Nature· 7 days agoA study on a soybean DNA demethylase reveals that seed size is negatively regulated by GmDMEa, which is closely linked to methylation on transposon elements.
Enhanced quantum coherence of plasmonic resonances with a chiral exceptional points - Communications...
Nature· 6 days agoThe advent of non-Hermitian optics carries new possibilities in manipulating optical response, offering alternative ways to enhance the quantum coherence of plasmonic resonances. Based on a ...
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 7 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to ...
Expanding the phenotypic spectrum of NOTCH1 variants: clinical manifestations in families with...
Nature· 6 days agoPathogenic variants in NOTCH1 are associated with non-syndromic congenital heart disease (CHD) and Adams–Oliver syndrome (AOS). The clinical presentation of individuals with damaging NOTCH1 ...