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Circadian checkpoint - Nature Immunology
Nature· 1 day agoImmune cell function and responses to immune checkpoint blockade are affected by the time of day owing to circadian rhythms. Data now published in Cell examine the effects of circadian biology ...
Sex differences are skin deep - Nature Immunology
Nature· 1 day agoSex differences in the prevalence of cancer and autoimmunity and susceptibility to infectious disease have long been observed, but the underlying mechanisms responsible have remained unclear ...
Vaccination induces broadly neutralizing antibody precursors to HIV gp41 - Nature Immunology
Nature· 5 days agoSchief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.
Engineered CAR T cells repress signs and symptoms of allergic asthma in mice for a year
Medical Xpress· 7 days agoA team of molecular oncologists at Tsinghua University's State Key Laboratory of Molecular Oncology, in China, has found that engineered, long-lived and multifunctional T cells repress signs ...
Novel vaccine concept generates immune responses that could produce multiple types of HIV...
Medical Xpress· 5 days agoThe findings, published today in Nature Immunology, are an encouraging, incremental step in...
Study reveals circadian clock can be leveraged to enhance cancer immunotherapy
Medical Xpress· 7 days agoA multidisciplinary research team at the University of California, Irvine has revealed that the circadian clockâthe biological pacemaker that governs daily rhythms in physiological processes ...
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors - Nature ...
Nature· 5 days agoBatista, Schief and colleagues use a series of germline-targeting immunogens in knock-in mice expressing heavy chain sequences derived from the HIV broadly neutralizing antibody 10E8 to characterize ...
Fewer Suicides in Cancer Patients; Circadian Rhythm Boost; HIV Vaccine for Cancer?
MedPage Today· 4 days agoNews, features, and commentary about cancer-related issues
Researchers identify first step in allergic reactions, paving the way for preventative strategies
Medical Xpress· 12 hours agoIt is well established that when mast cells, a type of immune cell, mistake a harmless substance, such as peanuts or dust mites, as a threat, they release an immediate first wave of bioactive ...
Genetic changes identified as key to childhood lupus
Medical Xpress· 17 hours agoIn people with lupus the body's immune system mistakenly attacks its own cells and tissues. Until now, its exact cause has been unknown, but it was thought to be a combination of genetic and ...