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Circadian checkpoint - Nature Immunology
Nature· 16 hours agoImmune cell function and responses to immune checkpoint blockade are affected by the time of day owing to circadian rhythms. Data now published in Cell examine the effects of circadian biology ...
Sex differences are skin deep - Nature Immunology
Nature· 16 hours agoSex differences in the prevalence of cancer and autoimmunity and susceptibility to infectious disease have long been observed, but the underlying mechanisms responsible have remained unclear ...
Decoding HIV’s Defenses: Innovative Vaccine Strategy Shows Promise
SciTechDaily· 1 day agoResults from NIH-funded animal models will inform the development of vaccines for humans. Using...
Engineered CAR T cells repress signs and symptoms of allergic asthma in mice for a year
Medical Xpress· 6 days agoA team of molecular oncologists at Tsinghua University's State Key Laboratory of Molecular Oncology, in China, has found that engineered, long-lived and multifunctional T cells repress signs ...
Nociceptor-immune interactomes reveal insult-specific immune signatures of pain - Nature Immunology
Nature· 7 days agoWoolf and colleagues use single-cell transcriptomics to determine the gene signature of infiltrating immune cells and potential cell–cell interactions between receptors, ligands, ion channels ...
Genetic changes identified as key to childhood lupus
Medical Xpress· 2 hours agoIn people with lupus the body's immune system mistakenly attacks its own cells and tissues. Until now, its exact cause has been unknown, but it was thought to be a combination of genetic and ...
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors - Nature ...
Nature· 5 days agoBatista, Schief and colleagues use a series of germline-targeting immunogens in knock-in mice expressing heavy chain sequences derived from the HIV broadly neutralizing antibody 10E8 to characterize ...
Study reveals circadian clock can be leveraged to enhance cancer immunotherapy
Medical Xpress· 6 days agoA multidisciplinary research team at the University of California, Irvine has revealed that the circadian clock—the biological pacemaker that governs daily rhythms in physiological processes ...
Q&A: Researchers determine that a subclass of stem cells replenish platelets more rapidly
Medical Xpress· 8 hours agoMazzi: Platelets, the blood cells critical for preventing and stopping bleeding, are short-lived and in need of constant replenishment by blood-forming stem cells residing in the bone marrow ...
Vaccination induces broadly neutralizing antibody precursors to HIV gp41 - Nature Immunology
Nature· 5 days agoSchief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.
