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Circadian checkpoint - Nature Immunology
Nature· 2 days agoImmune cell function and responses to immune checkpoint blockade are affected by the time of day owing to circadian rhythms. Data now published in Cell examine the effects of circadian biology ...
Genetic changes identified as key to childhood lupus
Medical Xpress· 1 day agoIn people with lupus the body's immune system mistakenly attacks its own cells and tissues. Until now, its exact cause has been unknown, but it was thought to be a combination of genetic and ...
Sex differences are skin deep - Nature Immunology
Nature· 2 days agoSex differences in the prevalence of cancer and autoimmunity and susceptibility to infectious disease have long been observed, but the underlying mechanisms responsible have remained unclear ...
Vaccination induces broadly neutralizing antibody precursors to HIV gp41 - Nature Immunology
Nature· 6 days agoSchief and colleagues show that germline-targeting epitope scaffolds can elicit responses from rare broadly neutralizing antibody precursor B cells with predefined binding specificities and genetic features.
Affinity gaps among B cells in germinal centers drive the selection of MPER precursors - Nature ...
Nature· 6 days agoBatista, Schief and colleagues use a series of germline-targeting immunogens in knock-in mice expressing heavy chain sequences derived from the HIV broadly neutralizing antibody 10E8 to characterize ...
Novel vaccine concept generates immune responses that could produce multiple types of HIV...
Medical Xpress· 5 days agoThe findings, published today in Nature Immunology, are an encouraging, incremental step in...
Surprising find could lead to drugs for severe allergic reactions
Futurity· 7 hours agoThe discovery could pave way for the development of drugs to prevent these severe allergic...
Q&A: Researchers determine that a subclass of stem cells replenish platelets more rapidly
Medical Xpress· 1 day agoMazzi: Platelets, the blood cells critical for preventing and stopping bleeding, are short-lived and in need of constant replenishment by blood-forming stem cells residing in the bone marrow ...
Scientists find 'Goldilocks' binding strength determines anti-cancer T-cell efficacy and fate
Medical Xpress· 5 days agoSt. Jude Children's Research Hospital scientists found that how tight a parental T cell grabs a cancer protein determines if its daughter cells will be anti-cancer effectors or exhausted. T ...
Fewer Suicides in Cancer Patients; Circadian Rhythm Boost; HIV Vaccine for Cancer?
MedPage Today· 5 days agoNews, features, and commentary about cancer-related issues