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A Deeper Look at Anti-PD-1/PD-L1 Checkpoint Inhibitors for Cancer
Forbes· 5 days agoIn a previous story, I described pembrolizumab, a PD-1 targeting checkpoint inhibitor, in some...
Gilead (GILD), RCUS Announce Data From Colorectal Cancer Study
Zacks via Yahoo Finance· 1 day agoEtrumadenant is an investigational small molecule, selective dual antagonist of the A2a and A2b...
ASCO 2024: AbbVie flexes early success of ADC pipeline in solid tumours
Clinical Trials Arena via Yahoo Finance· 2 days agoABBV-706 is an ADC targeting SEZ6, a transmembrane protein expressed in various solid tumours,...
EMA Panel Nods to Seven New Cancer Drugs
Medscape· 5 days agoThe drugs include an anti–PD-L1 monoclonal antibody, a biosimilar, and five generics, with indications covering a wide spectrum of cancers.
... Etrumadenant Plus Zimberelimab Regimen Significantly Reduced the Risk of Death in Third-line...
Morningstar· 3 days agoGilead and Arcus Announce EtrumadenantPlus Zimberelimab Regimen Significantly Reduced the Risk of Death in Third-line Metastatic Colorectal Cancer – In Cohort B of the ARC ...
New study highlights senescent cell removal mechanisms of canagliflozin, a sodium glucose...
Medical Xpress· 6 days agoThe process of aging is accompanied by a decline in physiological functions, which can lead to...
Molecular Assassins: How Azoles Cause Fungal Pathogens to Self-Destruct
SciTechDaily· 5 days agoNew research led by the University of Exeter shows that azole antifungals trigger self-destruction...
CARVYKTI® (ciltacabtagene autoleucel) significantly improved progression-free survival and deepened...
Valley City Times Record· 1 day agoJohnson & Johnson announced today results from a subgroup analysis of the Phase 3 CARTITUDE-4 study. Data from the CARTITUDE-4 study supported the recent U.S. FDA approval of CARVYKTI®, the ...
Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial...
Nature· 7 days agoHigh glucose-induced HUVECs apoptosis was reduced by PKCδ inhibition with siRNA or rottlerin. RNA-seq identified two enzymes, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1 ...
Leads Biolabs' Innovative Cancer Treatment LBL-024, an Anti-PDL1/4-1BB Bispecific Antibody Achieved...
The Pendulum· 2 days agoAfter rigorous evaluation by Scientific Program Committee and ASCO Leadership, LBL-024, a bispecific antibody independently developed by Leads Biolabs with global intellectual ...