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Mitochondrial calcium uniporter promotes kidney aging in mice through inducing mitochondrial...
Nature· 3 days agoRenal tubular epithelial cell senescence plays a critical role in promoting and accelerating kidney aging and age-related renal fibrosis. Senescent cells not only lose their self-repair ability ...
Bio-stimulating effect of endophytic Aspergillus flavus AUMC 16068 and its respective...
Nature· 2 days agoHeavy metal accumulation is one of the major agronomic challenges that has seriously threatened food safety. As a result, metal-induced phytotoxicity concerns require quick and urgent action ...
In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated...
Nature· 3 days agoPartially reprogramming a specific population of neurons in the cerebral cortex of mice, improves cognition through greater activation in memory circuits and plasticity induced by the reorganization of the extracellular matrix.
Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 4 days agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative...
Nature· 2 days agoDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets. Spliceosome-related genes were significantly altered in HCC. Oncofetal ...
Higher surface folding of the human premotor cortex is associated with better long-term learning...
Nature· 2 days agoA brain imaging study shows that humans with more complex cortical folds in a premotor brain region have a higher capacity to learn a challenging new motor skill during six weeks of practice.
A DNA demethylase reduces seed size by decreasing the DNA methylation of AT-rich transposable...
Nature· 6 days agoA study on a soybean DNA demethylase reveals that seed size is negatively regulated by GmDMEa, which is closely linked to methylation on transposon elements.
KDM5B promotes SMAD4 loss-driven drug resistance through activating DLG1/YAP to induce lipid...
Nature· 3 days agoInactivated suppressor of mothers against decapentaplegic homolog (SMAD) 4 significantly affects cancer development in pancreatic ductal adenocarcinoma (PDAC). However, the contribution of smad4 ...
Neurophysiological avenues to better conceptualizing adaptive cognition - Communications Biology
Nature· 3 days agoThis article explores novel routes to better analyze neural processes underlying the brain’s adaptability and cognitive functioning, focusing on executive functions and cognitive control. It ...
Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to...
Nature· 3 days agoCaspase-8 (Casp8) serves as an initiator of apoptosis or a suppressor of necroptosis in context-dependent manner. Members of the p90 RSK family can phosphorylate caspase-8 at threonine-265 ( ...