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Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 47 minutes agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny...
Nature· 4 hours agoAutism spectrum disorders (ASDs) are known to present sex-specific differences. At the same time, understanding how maternal behaviours are affected by pathogenic mutations is crucial to translate ...
Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing...
Nature· 1 day agoSingle-cell atlas of Microhyla fissipes lungs reveals cell differentiation and functionalization during metamorphosis, further cross-species comparison sheds light vertebrate lung cell type evolution.
Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability - Molecular...
Nature· 1 day agoAs the most prescribed psychotropic drugs in current medical practice, antidepressant drugs (ADs) of the selective serotonin reuptake inhibitor (SSRI) class represent prime candidates for drug ...
Reduced precipitation can induce ecosystem regime shifts in lakes by increasing internal nutrient...
Nature· 1 day agoEutrophication is a main threat to continental aquatic ecosystems. Prevention and amelioration actions have been taken under the assumption of a stable climate, which needs reconsideration.
Detection of inflammasome activation in liver tissue during the donation process as potential...
Nature· 1 day agoDeceased donor liver transplantation (LT) is a crucial lifesaving option for patients with end-stage liver diseases. Although donation after brain death (DBD) remains the main source of donated ...
Top medical journals continue to produce tobacco-funded research: Study
Investing.com· 3 hours agoThe findings by The Investigative Desk -- an independent platform for investigative journalism --...
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel...
Nature· 2 days agoCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were ...
Neural correlates of obesity across the lifespan - Communications Biology
Nature· 3 days agoThis study reveals that obesity-related brain changes evolve across the lifespan and involve mitochondrial and inflammatory genes, as well as neurochemical and cognitive alterations.
Molecular entanglement can strongly increase basicity - Communications Chemistry
Nature· 3 days agoBrønsted basicity can be greatly enhanced by the mechanical entanglement of two or more interlocked molecular subunits within catenanes and rotaxanes. Here, the authors discuss the development ...