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You’re not imagining it: extreme wildfires are now more common
Nature· 23 hours agoFor the first time, data show that cataclysmic infernos are increasing in frequency and intensity...
Ketamine induced synaptic plasticity operates independently of long-term potentiation -...
Nature· 6 days agoSynaptic plasticity occurs via multiple mechanisms to regulate synaptic efficacy. Homeostatic and Hebbian plasticity are two such mechanisms by which neuronal synapses can be altered. Although ...
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia -...
Nature· 5 days agoPRMT2 is a key regulator of inflammation in acute myeloid leukemia. PRMT2-deficient cells exhibit a pro-inflammatory profile associated with STAT3 activation.
Circadian rapid eye movement sleep expression is associated with brain microstructural integrity in...
Nature· 3 days agoThis study highlights the circadian regulation of rapid eye movement sleep as a neurophysiological correlate of subtle brain microstructural changes in key brain regions sensitive to aging and involved in sleep-wake regulation.
Could rats and dogs detect disease better than the finest lab equipment?
Nature· 6 days agoThe animals’ keen sense of smell could improve the detection of illnesses such as cancer and...
Florida man sneezes gut out at public diner
Newsweek· 7 hours agoA very unfortunate Florida man was having breakfast in a diner when a sneeze caused his guts to pop out of his body. The 63-year-old man, who had...
Ceftazidime is a potential drug to inhibit cell proliferation by increasing cellular p27 - The...
Nature· 6 days agoThe development of new therapeutic uses for existing drugs is important for the treatment of some diseases. Cephalosporin antibiotics stand as the most extensively utilized antibiotics in clinical ...
Structural basis of tolvaptan binding to the vasopressin V2 receptor - Acta Pharmacologica Sinica
Nature· 5 days agoThe vasopressin V2 receptor (V2R) is a validated therapeutic target for autosomal dominant polycystic kidney disease (ADPKD), with tolvaptan being the first FDA-approved antagonist. Herein, ...
hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under...
Nature· 6 days agoMitochondrial homeostasis is coordinated through communication between mitochondria and the nucleus. In response to stress, mitochondria generate retrograde signals to protect against their ...
How germ granules promote germ cell fate - Nature Reviews Genetics
Nature· 7 days agoIn this Review, Pamula and Lehmann describe how distinct membraneless germ granules organize the germ cell cytoplasm at different stages of the germline life cycle to determine germ cell identity ...