Search results
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia -...
Nature· 4 days agoPRMT2 is a key regulator of inflammation in acute myeloid leukemia. PRMT2-deficient cells exhibit a pro-inflammatory profile associated with STAT3 activation.
Circadian rapid eye movement sleep expression is associated with brain microstructural integrity in...
Nature· 2 days agoThis study highlights the circadian regulation of rapid eye movement sleep as a neurophysiological correlate of subtle brain microstructural changes in key brain regions sensitive to aging and involved in sleep-wake regulation.
hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under...
Nature· 5 days agoMitochondrial homeostasis is coordinated through communication between mitochondria and the nucleus. In response to stress, mitochondria generate retrograde signals to protect against their ...
Structural basis of tolvaptan binding to the vasopressin V2 receptor - Acta Pharmacologica Sinica
Nature· 4 days agoThe vasopressin V2 receptor (V2R) is a validated therapeutic target for autosomal dominant polycystic kidney disease (ADPKD), with tolvaptan being the first FDA-approved antagonist. Herein, ...
Ketamine induced synaptic plasticity operates independently of long-term potentiation -...
Nature· 5 days agoSynaptic plasticity occurs via multiple mechanisms to regulate synaptic efficacy. Homeostatic and Hebbian plasticity are two such mechanisms by which neuronal synapses can be altered. Although ...
Ceftazidime is a potential drug to inhibit cell proliferation by increasing cellular p27 - The...
Nature· 5 days agoThe development of new therapeutic uses for existing drugs is important for the treatment of some diseases. Cephalosporin antibiotics stand as the most extensively utilized antibiotics in clinical ...
Multiple omics levels of chronic lymphocytic leukemia - Cell Death Discovery
Nature· 3 days agoChronic lymphocytic leukemia (CLL) is a lymphoproliferative malignancy characterized by the proliferation of functionally mature but incompetent B cells. It is the most prevalent type of leukemia ...
Body size predicts ontogenetic nitrogen stable-isotope (δ15N) variation, but has little relationship...
Nature· 5 days agoLarge predators have disproportionate effects on their underlying food webs. Thus, appropriately assigning trophic positions has important conservation implications both for the predators themselves ...
Neural connectivity patterns explain why adolescents perceive the world as moving slow -...
Nature· 2 days agoAn EEG study using event segmentation theory found adolescents segment movies into fewer, longer episodes than adults. Differences in neural communication patterns between brain regions explain why younger people perceive the world as moving slower.
Could rats and dogs detect disease better than the finest lab equipment?
Nature· 6 days agoThe animals’ keen sense of smell could improve the detection of illnesses such as cancer and...