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Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia -...
Nature· 2 days agoPRMT2 is a key regulator of inflammation in acute myeloid leukemia. PRMT2-deficient cells exhibit a pro-inflammatory profile associated with STAT3 activation.
hnRNPH1 maintains mitochondrial homeostasis by establishing NRF1/DRP1 retrograde signaling under...
Nature· 3 days agoMitochondrial homeostasis is coordinated through communication between mitochondria and the nucleus. In response to stress, mitochondria generate retrograde signals to protect against their ...
Integrative analysis of single-cell RNA-seq and gut microbiome metabarcoding data elucidates...
Nature· 7 days agoChronic ulcerative colitis in mice is characterized by pro-inflammatory M1 macrophage phenotype and higher Nampt and NOX2 transcription, as well as a reduced taxonomic diversity in the mice gut microbiome.
Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer...
Nature· 5 days agoAging-related cancer incidence remains not fully understood. Here, the authors depict a progressive process of senescence in murine mammary stem cells at single-cell resolution, which is governed ...
Ceftazidime is a potential drug to inhibit cell proliferation by increasing cellular p27 - The...
Nature· 3 days agoThe development of new therapeutic uses for existing drugs is important for the treatment of some diseases. Cephalosporin antibiotics stand as the most extensively utilized antibiotics in clinical ...
Could rats and dogs detect disease better than the finest lab equipment?
Nature· 3 days agoThe animals’ keen sense of smell could improve the detection of illnesses such as cancer and...
How germ granules promote germ cell fate - Nature Reviews Genetics
Nature· 4 days agoIn this Review, Pamula and Lehmann describe how distinct membraneless germ granules organize the germ cell cytoplasm at different stages of the germline life cycle to determine germ cell identity ...
Gut microbiome discovery provides roadmap for life-saving cancer therapies
Nature· 2 days agoThe balance between bacterial communities in the gut affects the likelihood of a positive response...
Body size predicts ontogenetic nitrogen stable-isotope (δ15N) variation, but has little relationship...
Nature· 3 days agoLarge predators have disproportionate effects on their underlying food webs. Thus, appropriately assigning trophic positions has important conservation implications both for the predators themselves ...
Misinformation might sway elections — but not in the way that you think
Nature· 4 days agoRampant deepfakes and false news are often blamed for swaying votes. Research suggests it’s hard to...