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Local dominance unveils clusters in networks - Communications Physics
Nature· 1 day agoCommunity detection has been studied for more than 20 years, but a perspective from community center is still missing and most algorithms need global information. The authors propose a linear ...
Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide...
Nature· 1 day agoGenome-wide association study (GWAS) is a powerful tool to identify genomic loci underlying complex traits. However, the application in natural populations comes with challenges, especially ...
Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma...
Nature· 1 day agoIDO downregulation in dMDSCs induced by Toxoplasma gondii infection regulates expression of TGF-β and IL-10 through the Kyn/AhR/SP1 signal pathway, eventually contributing to the dysfunction of dNK cells.
Cryo-EM structure of cadmium-bound human ABCB6 - Communications Biology
Nature· 1 day agoCryo-EM structure of human ATP-binding cassette transporter 6 (ABCB6) in complex with Cd(II) and glutathione (GSH) provides molecular insight into its dual role, essential for heme biosynthesis and as a heavy metal efflux pump.
Autistic people three times more likely to develop Parkinson's-like symptoms
Nature· 5 days agoLargest study of its kind also finds increased risk in older adults with a range of intellectual...
Neural correlates of obesity across the lifespan - Communications Biology
Nature· 4 days agoThis study reveals that obesity-related brain changes evolve across the lifespan and involve mitochondrial and inflammatory genes, as well as neurochemical and cognitive alterations.
Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel...
Nature· 3 days agoCerebral small vessel disease (cSVD) is a leading cause of stroke and dementia. Genetic risk loci for white matter hyperintensities (WMH), the most common MRI-marker of cSVD in older age, were ...
Maternal behaviours disrupted by Gprasp2 deletion modulate neurodevelopmental trajectory in progeny...
Nature· 2 days agoAutism spectrum disorders (ASDs) are known to present sex-specific differences. At the same time, understanding how maternal behaviours are affected by pathogenic mutations is crucial to translate ...
PARP inhibition leads to synthetic lethality with key splicing-factor mutations in myelodysplastic...
Nature· 4 days agoSplicing factors are frequently mutated in patients with myelodysplastic syndromes and acute myeloid leukaemia. Recent studies have revealed convergent molecular defects caused by splicing factor ...
Multidimensional primate niche space sheds light on interspecific competition in primate evolution -...
Nature· 5 days ago7-dimensional niche space of 191 primate species shows niche diversity is partitioned unequally. Interspecific competition is lowest in great apes and highest in callitrichids.