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Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative...
Nature· 1 day agoDue to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets. Spliceosome-related genes were significantly altered in HCC. Oncofetal ...
Melatonin alleviates septic ARDS by inhibiting NCOA4-mediated ferritinophagy in alveolar macrophages...
Nature· 2 days agoFerroptosis is a novel form of programmed cell death which can exacerbate lung injury in septic acute respiratory distress syndrome (ARDS). Alveolar macrophages, crucial innate immune cells, ...
Induced dual-target rebalance simultaneously enhances efficient therapeutical efficacy in tumors -...
Nature· 3 days agoMultiple gene abnormalities are major drivers of tumorigenesis. NF-κB p65 overactivation and cGAS silencing are important triggers and genetic defects that accelerate tumorigenesis. However, ...
Elon Musk says the match he had with a sumo wrestler was 'a few minutes of glory' that became '8...
Business Insider· 6 days agoMusk posted a photo of a fight he once had with a sumo wrestler in March 2022. He did not specify...
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury - Communications...
Nature· 3 days agoActivation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
p52-ZER6/IGF1R axis maintains cancer stem cell population to promote cancer progression by enhancing...
Nature· 5 days agoCancer stem cells (CSCs), which are distinct subpopulations of tumor cells, have a substantially higher tumor-initiating capacity and are closely related to poor clinical outcomes. Damage to ...
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy - Cell Death &...
Nature· 3 days agoThe pseudokinase mixed lineage kinase domain-like (MLKL) is an essential component of the activation of the necroptotic pathway. Emerging evidence suggests that MLKL plays a key role in liver ...
Singapore sports round-up (13-19 May): Max Maeder wins 2nd world kitefoiling title, Geylang and...
Yahoo News Singapore· 6 days agoIt was an all-Singapore affair in the U-19 mixed doubles final as Loy Xing Yao, 15, and sister Ming...
Construction of TiO2/WO3/TiO2 double heterojunction films for excellent electrochromic performance -...
Nature· 6 days agoElectrochromic devices are applied extensively to camouflages, smart windows, heat insulation layers, and automobile rearview mirrors, etc. The amorphous WO3 is a very attractive electrochromic ...
She Devoted Herself to Teaching About the Tiananmen Massacre. Hong Kong Shunned Her.
The Wall Street Journal· 7 days agoThey also asked whether she had links with the Canadian or U.S. governments, or any political or...